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Fig. 1 | BMC Gastroenterology

Fig. 1

From: Therapy susceptible germline-related BRCA 1-mutation in a case of metastasized mixed adeno-neuroendocrine carcinoma (MANEC) of the small bowel

Fig. 1

a Primary MANEC of the ileum (HE, 2,5×) showing the gland-forming adenocarcinoma-component (left side) as well as the solid forming neuroendocrine carcinoma component (right side); b the gland forming adenocarcinoma showing PAS-positive mucins in gland lumina (PAS, 20×); c the solid growth-pattern of the neuroendocrine carcinoma component (HE, 20×); d Immunohistochemistry using an antibody against synaptophysin – diffuse and strong positivity of all tumor cells in the neuroendocrine-carcinoma component (synaptophysin, 5×); e Immunohisto-chemistry using an antibody against chromogranin A – more patchy positivity in the neuroendocrine-carcinoma component (chromogranin A, 5×) f1 Metastasis in liver and f2 in the brain, both formed by the adenocarcinoma component (HE, 10× and 20×)

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