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Table 2 Distribution of HLA-DQ genotypes in patients with celiac disease and control

From: HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation

HLA

Genotype

Patient (n = 49)

Control (n = 58)

Odds ratio

95% CL

Relative risk

P-value

n

Fr (%)

n

Fr (%)

DQ2.5/DQ8

5

10.2

1

1.7

6.48

0.73–57.46

1/10

0.09

DQ2.5/DQ2.5

24

49

6

10.3

8.32

3.02–22.93

1/12.5

< 0.01

DQ2.5/DQ2.2

5

10.2

2

3.4

3.18

0.59–17.19

1/20

0.18

DQ8/DQX

4

8.2

2

3.4

2.49

0.44–14.21

1/25

0.31

DQ2.5/DQ7

8

16.3

4

6.9

2.63

0.74–9.35

1/25

0.13

DQ2.2/DQ8

1

2

1

1.7

1.19

0.07–19.92

1/50

0.90

DQ2.2/DQ2.2

2

4.1

3

5.2

0.78

0.13–4.87

1/100

0.79

DQ2.x

0

0

4

6.9

0.12

0.01–2.33

0

0.16

DQX/DQX

0

0

35

60.3

0.01

0.00–0.11

0

< 0.01

  1. n number of the patients or the control, Fr frequency. Odds ratio and P-values have been calculated on the total data set comparing CD patients versus the control genotypes. Relative risk of developing disease for specific genotypes were calculated as a ratio of specific HLA-DQ genotype proportion in CD patients and control by taking into account the prevalence of the CD (0.016) in Syrian population