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Table 2 Distribution of HLA-DQ genotypes in patients with celiac disease and control

From: HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation

HLA Genotype Patient (n = 49) Control (n = 58) Odds ratio 95% CL Relative risk P-value
n Fr (%) n Fr (%)
DQ2.5/DQ8 5 10.2 1 1.7 6.48 0.73–57.46 1/10 0.09
DQ2.5/DQ2.5 24 49 6 10.3 8.32 3.02–22.93 1/12.5 < 0.01
DQ2.5/DQ2.2 5 10.2 2 3.4 3.18 0.59–17.19 1/20 0.18
DQ8/DQX 4 8.2 2 3.4 2.49 0.44–14.21 1/25 0.31
DQ2.5/DQ7 8 16.3 4 6.9 2.63 0.74–9.35 1/25 0.13
DQ2.2/DQ8 1 2 1 1.7 1.19 0.07–19.92 1/50 0.90
DQ2.2/DQ2.2 2 4.1 3 5.2 0.78 0.13–4.87 1/100 0.79
DQ2.x 0 0 4 6.9 0.12 0.01–2.33 0 0.16
DQX/DQX 0 0 35 60.3 0.01 0.00–0.11 0 < 0.01
  1. n number of the patients or the control, Fr frequency. Odds ratio and P-values have been calculated on the total data set comparing CD patients versus the control genotypes. Relative risk of developing disease for specific genotypes were calculated as a ratio of specific HLA-DQ genotype proportion in CD patients and control by taking into account the prevalence of the CD (0.016) in Syrian population