A subclinical high tricuspid regurgitation pressure gradient independent of the mean pulmonary artery pressure is a risk factor for the survival after living donor liver transplantation

Table 3 The survival rate and clinical characteristics

	3-month survival-related factors	12-month survival-related factors				40-month survival-related factors
	Univariate p-value	Univariate p-value	Risk ratio	95% CI	Multivariate p-value	Univariate p-value	Risk ratio	95% CI	Multivariate p-value
Total
Recipient age (years)
≥ 58	0.674	0.389				0.199
< 58
Donor age (years)
≥ 39	0.089	0.065				0.022 ^*	4.14	1.41–15.02	0.008 ^*
< 39
Sex
Male	0.516	0.507				0.251
Female
Baseline liver disease
HCV	0.874	0.981				0.897
HBV
NASH
Others
HCC
(+)	0.255	0.852				0.883
(−)
MELD
≥ 21	0.150	0.006 ^*	1.46	0.43–4.59	0.518	0.005 ^*	2.23	0.72–6.33	0.153
< 21
Past history of variceal treatment
(+)	0.676	0.414				0.619
(−)
pO₂ (mmHg)
≥ 83.8	0.640	0.324				0.155
< 83.8
AaDO₂ (mmHg)
≥ 15.9	0.694	0.776				0.489
< 15.9
Subclinical HPS
(+)	0.629	0.274				0.057
(−)
Subclinical high-TRPG
(+)	0.004 ^*	0.001 ^*	7.30	1.82–48.62	0.003 ^*	0.002 ^*	4.01	1.33–14.75	0.012 ^*
(−)
mPAP-FIO₂0.6
≥ 25	0.660	0.152				0.097
< 25
Ejection fraction (%)
≥ 71	0.901	0.461				0.564
< 71
Left atrial diameter (mm)
≥ 38.0	0.432	0.982				0.544
< 38.0
Perioperative blood loss volume (ml)
≥ 4910	0.092	0.242				0.295
< 4910
Graft recipient weight ratio
≥ 0.92	0.258	0.057				0.209
< 0.92

HCV hepatitis C virus-related cirrhosis, HBV hepatitis B virus-related cirrhosis, NASH non-alcoholic steatohepatitis-related cirrhosis, HCC hepatocellular carcinoma, MELD model for end-stage liver disease, AaDO₂ alveolar-arterial oxygen gradient, HPS hepato-pulmonary syndrome, TRPG tricuspid regurgitation pressure gradient, mPAP-FIO₂0.6 mean pulmonary artery pressure measured after general anesthesia with FIO₂0.6
^*p < 0.05

ISSN: 1471-230X