Severity of IBS-D | Probiotic (Bio-Kult®) (n = 181) | Placebo (n = 179) | P-value |
---|---|---|---|
Baseline | |||
Moderate | 39 (21.5) | 52 (29.1) | 0.101 |
Severe | 142 (78.5) | 127 (70.9) | |
Month 1 | |||
Symptoms free period | 2 (1.1) | 2 (1.1) | 0.086 |
Mild | 78 (43.1) | 58 (32.4) | |
Moderate | 91 (50.3) | 99 (55.3) | |
Severe | 10 (5.5) | 20 (11.2) | |
Month 2 | |||
Symptoms free period | 16 (8.8) | 18 (10.1) | < 0.001 |
Mild | 112 (61.9) | 61 (34.1) | |
Moderate | 42 (23.2) | 82 (45.8) | |
Severe | 11 (6.1) | 18 (10.1) | |
Month 3 | |||
Symptoms free period | 54 (29.8) | 20 (11.2) | < 0.001 |
Mild | 98 (54.1) | 62 (34.6) | |
Moderate | 23 (12.7) | 57 (31.8) | |
Severe | 6 (3.3) | 40 (22.3) | |
Month 4 | |||
Symptoms free period | 56 (30.4) | 22 (11.2) | < 0.001 |
Mild | 99 (54.7) | 68 (38.0) | |
Moderate | 21 (11.6) | 66 (36.9) | |
Severe | 6 (3.3) | 23 (12.8) | |
Follow-up: Month 5 | |||
Symptoms free period | 61 (33.7) | 23 (12.8) | < 0.001 |
Mild | 95 (52.5) | 70 (39.1) | |
Moderate | 21 (11.6) | 65 (36.3) | |
Severe | 4 (2.2) | 21 (11.7) |