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Table 2 IBS symptom scores at baseline, during 16 weeks’ treatment and after one month’s follow-up

From: A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation (Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome

 

Probiotic (Bio-Kult®) (n = 181)

Placebo (n = 179)

P-value

Overall IBS-SSS scores

Before treatment

333.0 ± 40.4

332.9 ± 42.0

0.992

Month 1

187.9 ± 61.3

215.4 ± 75.0

< 0.001

Month 2

146.5 ± 76.4

188.0 ± 92.0

< 0.001

Month 3

122.0 ± 78.3

199.5 ± 104.1

< 0.001

Month 4

115.2 ± 75.0

179.7 ± 100.2

< 0.001

Month 5

110.0 ± 71.8

176.0 ± 100.0

< 0.001

IBS-SSS: Severity score of abdominal pain

Before treatment

58.5 ± 11.1

57.2 ± 10.6

0.264

Month 1

30.3 ± 14.8

35.3 ± 15.9

0.002

Month 2

23.8 ± 16.2

31.1 ± 18.8

< 0.001

Month 3

20.3 ± 15.8

33.1 ± 19.7

< 0.001

Month 4

18.5 ± 16.2

30.4 ± 20.3

< 0.001

Month 5

18.1 ± 15.2

30.2 ± 19.9

< 0.001

IBS-SSS: Number of days in the last 10 days with pain

Before treatment

7.7 ± 2.3

8.1 ± 2.3

0.056

Month 1

3.6 ± 2.1

4.4 ± 2.5

0.001

Month 2

2.9 ± 2.3

3.8 ± 2.7

0.001

Month 3

2.5 ± 2.2

4.2 ± 2.8

< 0.001

Month 4

2.4 ± 2.1

4.1 ± 3.2

< 0.001

Month 5

2.2 ± 1.9

3.9 ± 3.0

< 0.001

IBS-SSS: Severity score of abdominal distension

Before treatment

58.5 ± 11.5

58.9 ± 12.0

0.695

Month 1

34.2 ± 16.2

38.4 ± 19.3

0.028

Month 2

25.7 ± 16.9

35.6 ± 20.2

< 0.001

Month 3

21.1 ± 16.4

37.5 ± 22.3

< 0.001

Month 4

20.1 ± 16.6

36.3 ± 23.3

< 0.001

Month 5

19.6 ± 15.8

35.9 ± 23.5

< 0.001

IBS-SSS: Satisfaction score for bowel symptoms

Before treatment

71.0 ± 9.7

69.6 ± 13.1

0.256

Month 1

44.9 ± 14.2

50.3 ± 16.9

0.001

Month 2

34.3 ± 17.2

43.0 ± 19.6

< 0.001

Month 3

29.6 ± 18.3

45.5 ± 22.5

< 0.001

Month 4

28.0 ± 18.9

43.3 ± 23.8

< 0.001

Month 5

26.5 ± 19.1

42.2 ± 25.0

< 0.001

Highest number of bowel motions per day

Before treatment

6.1 ± 2.6

5.6 ± 1.8

0.024

Month 1

3.3 ± 1.4

3.3 ± 1.4

0.891

Month 2

2.9 ± 1.2

3.2 ± 1.3

0.043

Month 3

3.0 ± 1.5

3.6 ± 1.3

< 0.001

Month 4

2.7 ± 1.5

3.5 ± 1.3

< 0.001

Month 5

2.5 ± 1.4

3.4 ± 1.4

< 0.001

Passing excess mucus [no. pts. (%)]

Before treatment

181 (100.0)

179 (100.0)

 

Month 1

170 (93.9)

177 (98.9)

0.012

Month 2

175 (96.7)

175 (97.8)

0.748

Month 3

175 (98.9)

177 (98.9)

0.157

Month 4

171 (94.5)

174 (97.2)

0.195

Month 5

168 (92.8)

171 (95.5)

0.272

IBS-SSS: Score of IBS affecting or interfering with life

Before treatment

68.6 ± 12.6

66.1 ± 11.1

0.049

Month 1

42.5 ± 15.0

47.4 ± 16.6

0.004

Month 2

33.4 ± 17.2

40.6 ± 19.7

< 0.001

Month 3

26.0 ± 17.9

41.8 ± 23.4

< 0.001

Month 4

24.9 ± 16.5

29.1 ± 19.6

0.028

Month 5

23.4 ± 17.4

28.2 ± 20.1

0.015

  1. The unpaired t-test was used to determine the level of statistical significance