|
Overall IBS-SSS scores
|
|
Before treatment
|
333.0 ± 40.4
|
332.9 ± 42.0
|
0.992
|
|
Month 1
|
187.9 ± 61.3
|
215.4 ± 75.0
|
< 0.001
|
|
Month 2
|
146.5 ± 76.4
|
188.0 ± 92.0
|
< 0.001
|
|
Month 3
|
122.0 ± 78.3
|
199.5 ± 104.1
|
< 0.001
|
|
Month 4
|
115.2 ± 75.0
|
179.7 ± 100.2
|
< 0.001
|
|
Month 5
|
110.0 ± 71.8
|
176.0 ± 100.0
|
< 0.001
|
|
IBS-SSS: Severity score of abdominal pain
|
|
Before treatment
|
58.5 ± 11.1
|
57.2 ± 10.6
|
0.264
|
|
Month 1
|
30.3 ± 14.8
|
35.3 ± 15.9
|
0.002
|
|
Month 2
|
23.8 ± 16.2
|
31.1 ± 18.8
|
< 0.001
|
|
Month 3
|
20.3 ± 15.8
|
33.1 ± 19.7
|
< 0.001
|
|
Month 4
|
18.5 ± 16.2
|
30.4 ± 20.3
|
< 0.001
|
|
Month 5
|
18.1 ± 15.2
|
30.2 ± 19.9
|
< 0.001
|
|
IBS-SSS: Number of days in the last 10 days with pain
|
|
Before treatment
|
7.7 ± 2.3
|
8.1 ± 2.3
|
0.056
|
|
Month 1
|
3.6 ± 2.1
|
4.4 ± 2.5
|
0.001
|
|
Month 2
|
2.9 ± 2.3
|
3.8 ± 2.7
|
0.001
|
|
Month 3
|
2.5 ± 2.2
|
4.2 ± 2.8
|
< 0.001
|
|
Month 4
|
2.4 ± 2.1
|
4.1 ± 3.2
|
< 0.001
|
|
Month 5
|
2.2 ± 1.9
|
3.9 ± 3.0
|
< 0.001
|
|
IBS-SSS: Severity score of abdominal distension
|
|
Before treatment
|
58.5 ± 11.5
|
58.9 ± 12.0
|
0.695
|
|
Month 1
|
34.2 ± 16.2
|
38.4 ± 19.3
|
0.028
|
|
Month 2
|
25.7 ± 16.9
|
35.6 ± 20.2
|
< 0.001
|
|
Month 3
|
21.1 ± 16.4
|
37.5 ± 22.3
|
< 0.001
|
|
Month 4
|
20.1 ± 16.6
|
36.3 ± 23.3
|
< 0.001
|
|
Month 5
|
19.6 ± 15.8
|
35.9 ± 23.5
|
< 0.001
|
|
IBS-SSS: Satisfaction score for bowel symptoms
|
|
Before treatment
|
71.0 ± 9.7
|
69.6 ± 13.1
|
0.256
|
|
Month 1
|
44.9 ± 14.2
|
50.3 ± 16.9
|
0.001
|
|
Month 2
|
34.3 ± 17.2
|
43.0 ± 19.6
|
< 0.001
|
|
Month 3
|
29.6 ± 18.3
|
45.5 ± 22.5
|
< 0.001
|
|
Month 4
|
28.0 ± 18.9
|
43.3 ± 23.8
|
< 0.001
|
|
Month 5
|
26.5 ± 19.1
|
42.2 ± 25.0
|
< 0.001
|
|
Highest number of bowel motions per day
|
|
Before treatment
|
6.1 ± 2.6
|
5.6 ± 1.8
|
0.024
|
|
Month 1
|
3.3 ± 1.4
|
3.3 ± 1.4
|
0.891
|
|
Month 2
|
2.9 ± 1.2
|
3.2 ± 1.3
|
0.043
|
|
Month 3
|
3.0 ± 1.5
|
3.6 ± 1.3
|
< 0.001
|
|
Month 4
|
2.7 ± 1.5
|
3.5 ± 1.3
|
< 0.001
|
|
Month 5
|
2.5 ± 1.4
|
3.4 ± 1.4
|
< 0.001
|
|
Passing excess mucus [no. pts. (%)]
|
|
Before treatment
|
181 (100.0)
|
179 (100.0)
| |
|
Month 1
|
170 (93.9)
|
177 (98.9)
|
0.012
|
|
Month 2
|
175 (96.7)
|
175 (97.8)
|
0.748
|
|
Month 3
|
175 (98.9)
|
177 (98.9)
|
0.157
|
|
Month 4
|
171 (94.5)
|
174 (97.2)
|
0.195
|
|
Month 5
|
168 (92.8)
|
171 (95.5)
|
0.272
|
|
IBS-SSS: Score of IBS affecting or interfering with life
|
|
Before treatment
|
68.6 ± 12.6
|
66.1 ± 11.1
|
0.049
|
|
Month 1
|
42.5 ± 15.0
|
47.4 ± 16.6
|
0.004
|
|
Month 2
|
33.4 ± 17.2
|
40.6 ± 19.7
|
< 0.001
|
|
Month 3
|
26.0 ± 17.9
|
41.8 ± 23.4
|
< 0.001
|
|
Month 4
|
24.9 ± 16.5
|
29.1 ± 19.6
|
0.028
|
|
Month 5
|
23.4 ± 17.4
|
28.2 ± 20.1
|
0.015
|
