Probiotic (Bio-Kult®) (n = 181) | Placebo (n = 179) | P-value | |
---|---|---|---|
Overall IBS-SSS scores | |||
Before treatment | 333.0 ± 40.4 | 332.9 ± 42.0 | 0.992 |
Month 1 | 187.9 ± 61.3 | 215.4 ± 75.0 | < 0.001 |
Month 2 | 146.5 ± 76.4 | 188.0 ± 92.0 | < 0.001 |
Month 3 | 122.0 ± 78.3 | 199.5 ± 104.1 | < 0.001 |
Month 4 | 115.2 ± 75.0 | 179.7 ± 100.2 | < 0.001 |
Month 5 | 110.0 ± 71.8 | 176.0 ± 100.0 | < 0.001 |
IBS-SSS: Severity score of abdominal pain | |||
Before treatment | 58.5 ± 11.1 | 57.2 ± 10.6 | 0.264 |
Month 1 | 30.3 ± 14.8 | 35.3 ± 15.9 | 0.002 |
Month 2 | 23.8 ± 16.2 | 31.1 ± 18.8 | < 0.001 |
Month 3 | 20.3 ± 15.8 | 33.1 ± 19.7 | < 0.001 |
Month 4 | 18.5 ± 16.2 | 30.4 ± 20.3 | < 0.001 |
Month 5 | 18.1 ± 15.2 | 30.2 ± 19.9 | < 0.001 |
IBS-SSS: Number of days in the last 10 days with pain | |||
Before treatment | 7.7 ± 2.3 | 8.1 ± 2.3 | 0.056 |
Month 1 | 3.6 ± 2.1 | 4.4 ± 2.5 | 0.001 |
Month 2 | 2.9 ± 2.3 | 3.8 ± 2.7 | 0.001 |
Month 3 | 2.5 ± 2.2 | 4.2 ± 2.8 | < 0.001 |
Month 4 | 2.4 ± 2.1 | 4.1 ± 3.2 | < 0.001 |
Month 5 | 2.2 ± 1.9 | 3.9 ± 3.0 | < 0.001 |
IBS-SSS: Severity score of abdominal distension | |||
Before treatment | 58.5 ± 11.5 | 58.9 ± 12.0 | 0.695 |
Month 1 | 34.2 ± 16.2 | 38.4 ± 19.3 | 0.028 |
Month 2 | 25.7 ± 16.9 | 35.6 ± 20.2 | < 0.001 |
Month 3 | 21.1 ± 16.4 | 37.5 ± 22.3 | < 0.001 |
Month 4 | 20.1 ± 16.6 | 36.3 ± 23.3 | < 0.001 |
Month 5 | 19.6 ± 15.8 | 35.9 ± 23.5 | < 0.001 |
IBS-SSS: Satisfaction score for bowel symptoms | |||
Before treatment | 71.0 ± 9.7 | 69.6 ± 13.1 | 0.256 |
Month 1 | 44.9 ± 14.2 | 50.3 ± 16.9 | 0.001 |
Month 2 | 34.3 ± 17.2 | 43.0 ± 19.6 | < 0.001 |
Month 3 | 29.6 ± 18.3 | 45.5 ± 22.5 | < 0.001 |
Month 4 | 28.0 ± 18.9 | 43.3 ± 23.8 | < 0.001 |
Month 5 | 26.5 ± 19.1 | 42.2 ± 25.0 | < 0.001 |
Highest number of bowel motions per day | |||
Before treatment | 6.1 ± 2.6 | 5.6 ± 1.8 | 0.024 |
Month 1 | 3.3 ± 1.4 | 3.3 ± 1.4 | 0.891 |
Month 2 | 2.9 ± 1.2 | 3.2 ± 1.3 | 0.043 |
Month 3 | 3.0 ± 1.5 | 3.6 ± 1.3 | < 0.001 |
Month 4 | 2.7 ± 1.5 | 3.5 ± 1.3 | < 0.001 |
Month 5 | 2.5 ± 1.4 | 3.4 ± 1.4 | < 0.001 |
Passing excess mucus [no. pts. (%)] | |||
Before treatment | 181 (100.0) | 179 (100.0) | |
Month 1 | 170 (93.9) | 177 (98.9) | 0.012 |
Month 2 | 175 (96.7) | 175 (97.8) | 0.748 |
Month 3 | 175 (98.9) | 177 (98.9) | 0.157 |
Month 4 | 171 (94.5) | 174 (97.2) | 0.195 |
Month 5 | 168 (92.8) | 171 (95.5) | 0.272 |
IBS-SSS: Score of IBS affecting or interfering with life | |||
Before treatment | 68.6 ± 12.6 | 66.1 ± 11.1 | 0.049 |
Month 1 | 42.5 ± 15.0 | 47.4 ± 16.6 | 0.004 |
Month 2 | 33.4 ± 17.2 | 40.6 ± 19.7 | < 0.001 |
Month 3 | 26.0 ± 17.9 | 41.8 ± 23.4 | < 0.001 |
Month 4 | 24.9 ± 16.5 | 29.1 ± 19.6 | 0.028 |
Month 5 | 23.4 ± 17.4 | 28.2 ± 20.1 | 0.015 |