Skip to main content

Table 2 IBS symptom scores at baseline, during 16 weeks’ treatment and after one month’s follow-up

From: A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation (Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome

  Probiotic (Bio-Kult®) (n = 181) Placebo (n = 179) P-value
Overall IBS-SSS scores
Before treatment 333.0 ± 40.4 332.9 ± 42.0 0.992
Month 1 187.9 ± 61.3 215.4 ± 75.0 < 0.001
Month 2 146.5 ± 76.4 188.0 ± 92.0 < 0.001
Month 3 122.0 ± 78.3 199.5 ± 104.1 < 0.001
Month 4 115.2 ± 75.0 179.7 ± 100.2 < 0.001
Month 5 110.0 ± 71.8 176.0 ± 100.0 < 0.001
IBS-SSS: Severity score of abdominal pain
Before treatment 58.5 ± 11.1 57.2 ± 10.6 0.264
Month 1 30.3 ± 14.8 35.3 ± 15.9 0.002
Month 2 23.8 ± 16.2 31.1 ± 18.8 < 0.001
Month 3 20.3 ± 15.8 33.1 ± 19.7 < 0.001
Month 4 18.5 ± 16.2 30.4 ± 20.3 < 0.001
Month 5 18.1 ± 15.2 30.2 ± 19.9 < 0.001
IBS-SSS: Number of days in the last 10 days with pain
Before treatment 7.7 ± 2.3 8.1 ± 2.3 0.056
Month 1 3.6 ± 2.1 4.4 ± 2.5 0.001
Month 2 2.9 ± 2.3 3.8 ± 2.7 0.001
Month 3 2.5 ± 2.2 4.2 ± 2.8 < 0.001
Month 4 2.4 ± 2.1 4.1 ± 3.2 < 0.001
Month 5 2.2 ± 1.9 3.9 ± 3.0 < 0.001
IBS-SSS: Severity score of abdominal distension
Before treatment 58.5 ± 11.5 58.9 ± 12.0 0.695
Month 1 34.2 ± 16.2 38.4 ± 19.3 0.028
Month 2 25.7 ± 16.9 35.6 ± 20.2 < 0.001
Month 3 21.1 ± 16.4 37.5 ± 22.3 < 0.001
Month 4 20.1 ± 16.6 36.3 ± 23.3 < 0.001
Month 5 19.6 ± 15.8 35.9 ± 23.5 < 0.001
IBS-SSS: Satisfaction score for bowel symptoms
Before treatment 71.0 ± 9.7 69.6 ± 13.1 0.256
Month 1 44.9 ± 14.2 50.3 ± 16.9 0.001
Month 2 34.3 ± 17.2 43.0 ± 19.6 < 0.001
Month 3 29.6 ± 18.3 45.5 ± 22.5 < 0.001
Month 4 28.0 ± 18.9 43.3 ± 23.8 < 0.001
Month 5 26.5 ± 19.1 42.2 ± 25.0 < 0.001
Highest number of bowel motions per day
Before treatment 6.1 ± 2.6 5.6 ± 1.8 0.024
Month 1 3.3 ± 1.4 3.3 ± 1.4 0.891
Month 2 2.9 ± 1.2 3.2 ± 1.3 0.043
Month 3 3.0 ± 1.5 3.6 ± 1.3 < 0.001
Month 4 2.7 ± 1.5 3.5 ± 1.3 < 0.001
Month 5 2.5 ± 1.4 3.4 ± 1.4 < 0.001
Passing excess mucus [no. pts. (%)]
Before treatment 181 (100.0) 179 (100.0)  
Month 1 170 (93.9) 177 (98.9) 0.012
Month 2 175 (96.7) 175 (97.8) 0.748
Month 3 175 (98.9) 177 (98.9) 0.157
Month 4 171 (94.5) 174 (97.2) 0.195
Month 5 168 (92.8) 171 (95.5) 0.272
IBS-SSS: Score of IBS affecting or interfering with life
Before treatment 68.6 ± 12.6 66.1 ± 11.1 0.049
Month 1 42.5 ± 15.0 47.4 ± 16.6 0.004
Month 2 33.4 ± 17.2 40.6 ± 19.7 < 0.001
Month 3 26.0 ± 17.9 41.8 ± 23.4 < 0.001
Month 4 24.9 ± 16.5 29.1 ± 19.6 0.028
Month 5 23.4 ± 17.4 28.2 ± 20.1 0.015
  1. The unpaired t-test was used to determine the level of statistical significance