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Table 1 Prevalence of anti-SO antibodies of the IgG- and IgM-type in sera from patients with untreated PSC as compared to controls

From: Sulphite oxidase (SO) – a mitochondrial autoantigen as target for humoral and cellular immune reactions in primary sclerosing cholangitis

Diagnosis No. patients Antibodies to
SO-fl SO-I SO-II SO-III
   IgG-type: number (%) positive
Untreated PSC 30 13 (43) 7 (23) 6 (20) 3 (10)
PBC 95 0 *) 0 *) 0 *) 2 (2)
AIH 60 4 (7) *) 3 (5) *) 4 (7) *) 6 (10)
ALD 34 2 (6) *) 2 (6) *) 2 (6) 7 (20)
Hepatitis B or C 120 2 (2) *) 0 *) 2 (2) *) 9 (7)
Ulcerative colitis 43 4 (9) *) 2 (5) *) 3 (7) 3 (7)
Crohn’s disease 44 5 (11) *) 4 (9) 4 (9) 4 (9)
CTD 26 0 *) 0 *) 2 (8) 3 (11)
Blood donors 50 3 (6) *) 3 (6) *) 3 (6) 2 (4)
   IgM-type: number (%) positive
Untreated PSC 30 7 (23) 3 (10) 10 (33) 14 (47)
PBC 95 0 *) 0 *) 0 *) 0 *)
AIH 60 2 (3) *) 1 (2) 2 (3) *) 1 (2) *)
ALD 34 2 (6) *) 0 1 (3) *) 1 (3) *)
Hepatitis B or C 120 2 (2) *) 2 (2) 3 (2) *) 2 (2) *)
Ulcerative colitis 43 2 (5) *) 2 (5) 1 (2) *) 2 (5) *)
Crohn’s disease 44 1 (2) *) 1 (2) 5 (11) *) 4 (9) *)
CTD 26 0 **) 0 0 **) 0 **)
Blood donors 50 3 (6) *) 3 (6) 1 (2) *) 2 (4) *)
  1. *significantly lower as compared to patients with untreated PSC, p < 0.05