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Table 1 The timeline of the patient’s medical history and interventions

From: Case report: lactic acidosis and rhabdomyolysis during telbivudine and tenofovir treatment for chronic hepatitis B

Dates Summaries Diagnostic Testing Interventions
2002 Found HBV infection HBsAg, HBeAg, HBcAb positive No antiviral treatment
2013 Diagnosed with cirrhosis HBV DNA: 6.5*103 copies/ml Telbivudine
2013-2015.9   HBV DNA undetected Telbivudine
2015.9   HBV DNA: 7*103 copies/ml Telbivudine and Tenofovir
2015.9-2015.10 Myalgia and hypoesthesia in both lower limbs   Telbivudine and Tenofovir
2015.10 Myalgia and hypoesthesia not relieved   Adefovir
2015.11.17 Myalgia and hypoesthesia not relieved ALT 66 U/L, LDH 474 U/L, CPK 1050 U/L Adefovir; liver-protecting treatment
2015.11.25 Myalgia and hypoesthesia not relieved; Chest tightness and short of breath occurred Blood lactate 12.7 mmol/L, arterial blood gas: pH 7.25, base excess −21.1 mmol/L Adefovir; liver-protecting treatment
2015.11.27 (Admission) Myalgia, hypoesthesia, chest tightness, short of breath, palpitation; Swelling and tenderness of all extremities, muscle dumbness and grade 3 strength in both lower limbs ALT: 77 U/L, TBil: 25.2 μmol/L, CPK: 991 U/L, LDH: 509 U/L, creatine: 83 μmol/L, myoglobin: 1745 ng/ml, blood lactate: 20 mmol/L, HBV DNA undetected Entecavir; hemodialysis; hydration; alkalization
2015.12.4 Nearly all symptoms relieved gradually CPK 683 U/L, blood lactate 6.67 mmol/L Tenofovir, Methylprednisolone 40 mg qd
2016.1.13 Swelling of lower limbs disappeared CPK 47 U/L, blood lactate 3.21 mmol/L Tenofovir
2016.6 Walk naturally; Dumbness in distal limbs relieved but still existed HBV undetected Tenofovir
  1. HBV Hepatitis B virus, HBsAg Hepatitis B surface Antigen, HBeAg Hepatitis B envelope Antigen, HBcAb Hepatitis B core Antibody, ALT Alanine aminotransferase, LDH Lactate dehydrogenase, CPK Creatine phosphokinase, TBil Total Bilirubin