| |
Total n = 149
|
ESD-M n = 73
|
ESD-F n = 76
|
p value
|
ASD
|
|---|
|
Age (years)
| | | | | |
|
Mean ± SD
|
73.3 ± 8.6
|
73.0 ± 8.4
|
73.6 ± 8.7
|
0.67¶
|
0.0702
|
|
Median (range)
|
74 (52–91)
|
74 (52–91)
|
74 (52–90)
|
0.67§
| |
|
Gender
| | | |
0.4‡
| |
|
Male
|
97 (65.1%)
|
45 (61.6%)
|
52 (68.4%)
| |
0.143
|
|
Female
|
52 (34.9%)
|
28 (38.4%)
|
24 (31.6%)
| |
0.143
|
|
Underlying disease
| | | |
0.49‡
| |
|
None
|
132 (88.6%)
|
66 (90.4%)
|
66 (86.8%)
| |
0.113
|
|
Cardiomyopathy or cirrhosis
|
17 (11.4%)
|
7 (9.6%)
|
10 (13.2%)
| |
0.143
|
|
Antithrombotic drugs
| | | |
0.091‡
| |
|
None or discontinuation
|
143 (96.0%)
|
72 (98.6%)
|
71 (93.4%)
| |
0.268
|
|
Continuation
|
6 (4.0%)
|
1 (1.4%)
|
5 (6.6%)
| |
0.268
|
|
Location of lesions
| | | |
0.055†
| |
|
Upper
|
24 (16.1%)
|
12 (16.4%)
|
12 (15.8%)
| |
0.0163
|
|
Middle
|
54 (36.2%)
|
33 (45.2%)
|
21 (27.6%)
| |
0.372
|
|
Lower
|
71 (47.7%)
|
28 (38.4%)
|
43 (56.6%)
| |
0.371
|
|
Position of lesions
| | | |
0.44†
| |
|
Lesser curvature
|
60 (40.2%)
|
30 (41.1%)
|
30 (39.5%)
| |
0.0326
|
|
Greater curvature
|
38 (25.5%)
|
22 (30.1%)
|
16 (21.1%)
| |
0.207
|
|
Anterior wall
|
29 (19.5%)
|
11 (15.1%)
|
18 (23.7%)
| |
0.219
|
|
Posterior wall
|
22 (14.8%)
|
10 (13.7%)
|
12 (15.8%)
| |
0.0592
|
|
Morphology
| | | |
0.27†
| |
|
Protruding
|
55 (36.9%)
|
30 (41.1%)
|
25 (32.9%)
| |
0.170
|
|
Flat
|
1 (0.7%)
|
1 (1.4%)
|
0 (0%)
| |
0.169
|
|
Depressed
|
93 (63.4%)
|
42 (57.5%)
|
51 (67.1%)
| |
0.199
|
|
Histology
| | | |
0.68‡
| |
|
Differentiated
|
144 (96.6%)
|
70 (95.9%)
|
74 (97.4%)
| |
0.0834
|
|
Undifferentiated
|
5 (3.4%)
|
3 (4.1%)
|
2 (2.6%)
| |
0.0834
|
|
Lesion size (mm)
| | | | | |
|
Mean ± SD
|
16.6 ± 10.0
|
17.2 ± 9.3
|
16.1 ± 10.6
|
0.49¶
|
0.110
|
|
Median (range)
|
15 (3–77)
|
15 (3–40)
|
14 (4–77)
|
0.27§
| |
|
Specimen size (mm)
| | | | | |
|
Mean ± SD
|
39.0 ± 12.0
|
39.8 ± 11.6
|
38.2 ± 12.4
|
0.42¶
|
0.133
|
|
Median (range)
|
36 (17–110)
|
40 (17–75)
|
35 (20–110)
|
0.35§
| |
|
Depth
| | | |
0.68†
| |
|
pT1a
|
132 (88.6%)
|
63 (86.3%)
|
69 (90.8%)
| |
0.0724
|
|
pT1b1
|
7 (4.7%)
|
4 (5.5%)
|
3 (3.9%)
| |
0.0757
|
|
pT1b2
|
10 (6.7%)
|
6 (8.2%)
|
4 (5.3%)
| |
0.116
|
|
Presence of ulceration
|
17 (11.4%)
|
10 (13.7%)
|
7 (9.2%)
|
0.45‡
|
0.142
|
|
Operator level
| | | |
< 0.001‡
| |
|
Experts
|
70 (47.0%)
|
47 (64.4%)
|
23 (30.3%)
| |
0.727
|
|
Electrosurgical unit
| | | |
0.009‡
| |
|
VIO 300D
|
128 (85.9%)
|
57 (78.1%)
|
71 (93.4%)
| |
0.450
|
|
ICC200
|
21 (14.1%)
|
16 (21.9%)
|
5 (6.6%)
| |
0.450
|
- ESD endoscopic submucosal dissection, ESD-M endoscopic submucosal dissection with Splash-M knife, ESD-F endoscopic submucosal dissection with Flush Knife BT, SD standard deviation ASD absolute standardized difference
- p value was calculated using the χ2 test † and Fisher’s exact test ‡ for categorical data
- p value was calculated using the t test ¶ and the Mann-Whitney U test § for continuous data
- pT1a, tumor invasion is within mucosa; pT1b1, tumor invasion is within 0.5 mm of the muscularis mucosae; pT1b2, tumor invasion is 0.5 mm or deeper into the muscularis mucosae
