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Table 2 Percentage drop in total COX-induced short circuit current by selective inhibitors, COX-1 (SC-560) and COX-2 (Celecoxib)

From: Combined activity of COX-1 and COX-2 is increased in non-neoplastic colonic mucosa from colorectal neoplasia patients

  SC-560 Inhibition, SEM (%) Celecoxib Inhibition, SEM (%) p-value
CRN-pts (N/n = 15/26) 68.8 ± 4.5 53.7 ± 5.1 0.035*
Ctrls (N/n = 10/19) 80.6 ± 4.8 52.6 ± 10.3 0.028*
p-value 0.10 0.91  
  1. Horizontal p-values to the right show inhibition by SC-560 compared to inhibition by Celecoxib for CRN-pts and ctrls. Vertical p-values at the bottom show CRN-pts compared to ctrls for SC-560 inhibition and Celecoxib inhibition. Inhibition calculated as percentage selective COX-inhibition of total COX-inhibition. Total COX-inhibition defined as selective COX-inhibition + indomethacin inhibition. Percentage drop reflects the overall decreased activity. CRN-pts represent values for biopsies from colorectal neoplasia patients and ctrls values are for biopsies from patients without colorectal neoplasia. N = number of patients, n = number of biopsies, in parenthesis (N/n). * p-value < 0.05
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