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Table 2 Mutational status and copy number analysis for the TP53 gene and quantification of the centromeres of chromosome 17 in anal canal tumours according to HPV infection status and p16 expression

From: HPV positive, wild type TP53, and p16 overexpression correlate with the absence of residual tumors after chemoradiotherapy in anal squamous cell carcinoma

HPV negative /p16 negative FISH chromosome 17/ gene TP53 (%)
Case Protein Change Functional Consequence Exon 2/2 2/1 1/1 3/2 3/1 3/3 4/2 4/1
6 R282W Non-functional 8 60.5 28.0 10.0 1.5
7 R181L Partially functional 5 52.5 43.0 4.5
11 R273H Non-functional 8 69.0 23.0 4.5 3.5
16 G245S Non-functional 7 67.5 28.5 2.0 2.0
19 R273H Non-functional 8 70.0 24.5 4.0 1.5
23 R175P Non-functional 5 72.0 20.0 6.0 2.0   
31 R175H Non-functional 5 67.0 23.0 7.0 3.0
34 G245D Non-functional 7 64.5 20.5 10.0 3.0 2.0
49 R181C Partially functional 5 48.0 44.0 8.0
50 R181H Partially functional 5 44.5 49.5 6.0
59 R213Q Non-functional 6 64.0 26.0 6.5 3.5
60 R248W Non-functional 7 76.5 15.0 7.5 0.5 0.5
63 R175H Non-functional 5 68.0 22.5 5.5 4.0
64 C277F Non-functional 8 63.4 17.0 8.0 4.2 4.2 1.6 1.6
70 R273C Non-functional 8 63.0 19.0 7.5 7.5 2.0 1.0
72 R248Q Non-functional 7 65.0 17.5 9.5 4.0 1.5 1.5 1.0
75 R248Q Non-functional 7 67.0 18.5 7.5 3.0 1.5 1.5 1.0
76 R213Q Non-functional 6 65.0 25.5 5.5 4.0
77 R273C Non-functional 8 62.7 24.3 2.7 5.5 2.7 1.6 0.5
HPV positive/p16 borderline   2/2 2/1 1/1 3/2 3/1 3/3 4/2 4/1
29 G245S Non-functional 7 54.0 24.0 1.5 5.0 5.5 2.5 6.0 1.5
57 R181H Partially functional 5 59.0 23.0 10.5 1.5 2.0 1.0 1.5 1.5