Skip to main content
Fig. 3 | BMC Gastroenterology

Fig. 3

From: HPV positive, wild type TP53, and p16 overexpression correlate with the absence of residual tumors after chemoradiotherapy in anal squamous cell carcinoma

Fig. 3

Representative western blot of p16 (upper gel) and beta-actin (lower gel), which was used as an endogenous marker for normalization. Lanes are labelled at the top of the figure, and the case numbers for the patients analyzed are labelled at the bottom. Lanes 1–3 correspond to cases with mutations in TP53 that are negative for the HPV virus and p16 overexpression. Lanes 4 and 5 correspond to HPV positive cases with mutated TP53 and borderline p16 overexpression. Lanes 6, 7 and 8 correspond to cases with mutated TP53 that are negative for HPV and do not overexpress p16 (p16 expression similar to the normal anal mucosa tissue). Lanes 9–12 corresponded to samples with wild-type TP53 that are positive for HPV and exhibit p16 overexpression. Line 13 corresponds to a pool of p16 proteins extracted from five normal anal mucosal (NM) tissues

Back to article page

BMC Gastroenterology

ISSN: 1471-230X

Contact us