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Table 5 Characteristics of the five patients with unexplained chronic liver disease who underwent liver biopsy

From: Unexplained chronic liver disease in Ethiopia: a cross-sectional study

No. Sex Age (yr) Alcohol use Khat use Main symptoms and signs Main ultrasound findings ALT (U/L) AST (U/L) ALP (U/L) Albumin (g/L) Bilirubin (μmol/L) APRI scorea FIB-4 scoreb Biopsy delay (wk)
1 Female 26 Never 100 g/day, 10 yr Abdominal swelling; abdominal pain; nausea; diarrhoea; fatigue
Ascites
Heterogenous liver texture
Mild uneven liver surface
Gross ascites
Moderate splenomegaly
15 16 88 50 9 0.20 0.53 20
2 Male 25 Never 200 g/day, 5 yr Abdominal pain;
Diarrhea; arthralgia / myalgia
Heterogenous liver texture
Mild uneven liver surface
Periportal fibrosis
Moderate splenomegaly
15 19 107 46 19 0.74 1.92 33
3 Female 30 Never Never Abdominal swelling; abdominal pain
Ascites; umbilical hernia; non-specific rash
Heterogenous liver texture
Mild uneven liver surface
Gross ascites
Reduced liver span
43 44 258 20 5 0.68 1.25 64
4 Male 25 36 g/day × 1/wk., 3 yr 400 g/day × 3/wk., 5 yr Abdominal pain; nausea; diarrhea; arthralgia/myalgia Splenomegaly Heterogenous liver texture
Mild uneven liver surface
Splenomegaly
100 98 300 58 31 1.34 1.34 22
5 Female 25 Never Never Abdominal swelling; fatigue; peripheral oedema. Ascites Heterogenous liver texture
Mild uneven liver surface
Gross ascites
Reduced liver span
39 62 385 27 17 0.76 1.22 58
  1. Abbreviations: ALP alkaline phosphatase, ALT alanine aminotransferase, APRI aspartate aminotransferase to platelets ratio index, AST aspartate aminotransferase, URR upper reference range
  2. Laboratory reference ranges: ALT (8–40 U/L); AST (14–40 U/L); ALP (60–306 U/L); Albumin (35–52 g/L); Bilirubin (3–38 μmol/L) [21]
  3. aAPRI: (AST (U/L)/URR of AST (U/L))/platelet count (109/L) × 100
  4. bFIB-4: age (years) x AST (U/L)/(platelet count (109/L) x √ALT (U/L))