From: Symptoms and diagnostic criteria of acquired Megacolon - a systematic literature review
Author | Date | No. Pts | Findings |
---|---|---|---|
Kobak et al. [30] | 1962 | 2 | 1× nerve ganglia in rectal segment distal to megacolon, some diminution of ganglia in involved area 1× nerve ganglia observed entire colon |
Koch et al. [35] | 1993 | 6 | 1× CM hypertrophy 2× LM hypertrophy Diminished concentrations AChE in ME p < 0.01 Diminished concentrations VIP in ME p = 0.03 Diminished VIP-staining neurons CM + LM Diminished immunostaining neuronal bodies SPE Myenteric plexus, submuocus plexus externus, submucous plexus internus normal No inflammatory infiltrate |
Koch et al. [34] | 1996 | 10 | Diminished concentration VIP ME p = 0.01 Increased NADPH diaphorase activity in ME p = 0.01 |
Gattuso et al. [36] | 1996 | 3 | Hypertrophy ME Lower density NADPH-diaphorase in ME Decreased neural density shown by PGP 9.5 immunoreactivity Smaller number nitric oxide motor system nerve fibres in ME |
Gattuso et al. [32] | 1997 | 6 | No thickening enteric smooth muscle No change in density of enteric innervation 2× mild melanosis coli 3× mild chronic inflammatory cell infiltrate LP 2× hypertrophied ME No thickening enteric smooth muscle p < 0.005 2× fibrosis LM 1× fibrosis CM 3× fibrosis MM |
Gattuso et al. [27] | 1998 | 1 | Hypertrophy LM Hypertrophy MM Diminished enteric neural density in ME, most marked in LM Increased density AChE− + ve nerves in LP Mild-moderate fibrosis ME |
Lee et al. [23] | 2005 | 9 | Diminished ICC and PGP 9.5 reactive neuronal structures in all colonic layers p < 0.05 |
Meier-Ruge et al. [37] | 2006 | 63 | Atrophied collagenous tendinous connective tissue membrane of MP Atrophied tendinous fibre net of MP Type III collagen absent from MP ICC/collagen II/collagen IV/smooth muscle actin/desmin/fibronectin no consistent alteration |
Wedel et al. [38] | 2006 | 8 | SMMHC, HDAC8 and/or SM absent of lacking in 75% Diminished myofilaments of myocyte clusters Oligoneuronal hypogangliosis |
Iantorno et al. [24] | 2007 | 9 | Decreased enteric neurons and enteric glial cells Decreased ICC but increased ICC-IM Diminished NSE − +ve and S100 − +ve cells in SP and MP 67% lymphocyte infiltration MP and SP p = 0.13 |
Ohkubo et al. [39] | 2014 | 31 | Non-dilated loops exhibited similar histopathologic findings as dilated loops 61.3% damaged and/or severe reduction ganglion cells 35.5% atrophy and/or vacuolar degeneration of smooth muscle cells of MP 32.2% abnormal ICC network 19.4% atrophy and/or vacuolar degeneration of smooth muscle cells of MP and damaged and/or severe reduction ganglion cells 3.2% atrophy and/or vacuolar degeneration of smooth muscle cells of MP and abnormal ICC network 12.9% damaged and/or severe reduction ganglion cells and abnormal ICC network |