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Table 1 Characteristics of 7 eligible studies

From: Enteral immunonutrition versus enteral nutrition for gastric cancer patients undergoing a total gastrectomy: a systematic review and meta-analysis

Author (year) [Ref] Country Diagnosis Age of patients (Years) Sample size (EIN/EN) Elements of EIN Nature of EN EIN initiation time Total during time of nutrition support (days) Mode of enteral feeding Reported Outcomes
Liu et al. (2012) [18] China Advanced gastric cancer 57.3 ± 7.1 (EIN)
58.4 ± 6.3 (EN)
28/24 Arg and Gln Standard EN Post-operation 7 Nasoenteral Total protein, albumin, proalbumin, transrerrin, CD4+, CD8+, IgM, IgG, LHS, postoperative complications, incision infection, pulmonary infection
Okamoto et al. (2009) [20] Japan Gastric carcinoma 66.9 ± 11.5 (EIN)
70.9 ± 13.2(EN)
30/30 Arg, ω-3-FAs and RNA Standard EN Pre--operation 7 Oral CD4+, CD8+, CD4+/CD8+, SIRS, lymphocyte, LHS, postoperative complications, operation time, intraoperative blood loss
Chen et al. (2005) [10] China Gastric carcinoma unclear 20/20 Arg, Gln, and ω-3-FAs Standard EN Post-operation 7 Nasoenteral Proalbumin, albumin, transrerrin, CD4+, CD8+, CD4+/CD8+, IgM, IgG
Mochiki et al. (2011) [16] Japan Gastric cancer 65 ± 2.6 (EIN)
59 ± 2.1 (EN)
15/16 Gln Oral placebo Post-operation unclear Oral Operation time, intraoperative blood loss
Farreras et al. (2005) [19] Spain Gastric cancer 66.7 ± 8.3 (EIN)
69.2 ± 13.8(EN)
30/30 Arg,Gln and ω-3-FAs Standard EN Post-operation 7 Oral Total protein, proalbumin, albumin, lymphocyte, incision infection, pulmonary infection, postoperative complications, mortality
Marano et al. (2013) [21] Italy Gastric adenocarcinoma 66.6 (55-78) (EIN)
65.1 (49-83) (EN)
54/55 Arg,Gln, ω-3-FAs and RNA Standard EN Post-operation 7 Oral Total protein, albumin, transrerrin, CD4+, CD8+, lymphocyte, LHS, SIRS, postoperative complications, operation time, incision infection, mortality, intraoperative blood loss
Fujitani et al. (2012) [17] Japan Gastric adenocarcinoma 64 (26-78) (EIN)
65(30-79) (EN)
120/111 Arg and RNA Regular diet Pre--operation 5 Oral mortality, pulmonary infection, postoperative complications