| Day | Number | Total cholesterol (mmol/L) | LDL-C (mmol/L) | HDL-C (mmol/L) | Triglycerides (mmol/L) | ||||
---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | Mean | SD | Mean | SD | Mean | SD | |||
Healthy volunteers | ||||||||||
 Placebo | 1 | 12 | 4.70 | 0.964 | 2.78 | 0.853 | 1.38 | 0.298 | 1.189 | 0.3600 |
14 | 12 | 4.78 | 1.209 | 3.03 | 1.112 | 1.29 | 0.223 | 1.031 | 0.3635 | |
28 | 12 | 4.73 | 1.097 | 2.87 | 0.934 | 1.38 | 0.322 | 1.233 | 0.4302 | |
 Volixibat 0.5 mg | 1 | 10 | 4.17 | 0.933 | 2.39 | 0.861 | 1.35 | 0.314 | 0.976 | 0.3523 |
14 | 10 | 4.07 | 0.686 | 2.23 | 0.726 | 1.31 | 0.307 | 1.013 | 0.3370 | |
28 | 9 | 3.99 | 0.854 | 2.29 | 0.851 | 1.37 | 0.274 | 0.936 | 0.2013 | |
 Volixibat 1 mg | 1 | 9 | 4.28 | 0.628 | 2.43 | 0.650 | 1.34 | 0.274 | 0.863 | 0.3278 |
14 | 9 | 3.87 | 0.650 | 2.22 | 0.655 | 1.29 | 0.215 | 0.962 | 0.6851 | |
28 | 9 | 3.97 | 0.552 | 2.22 | 0.576 | 1.33 | 0.300 | 1.024 | 0.5973 | |
 Volixibat 5 mg | 1 | 8 | 4.53 | 0.865 | 2.81 | 0.781 | 1.25 | 0.227 | 1.476 | 0.6576 |
14 | 8 | 4.21 | 0.825 | 2.50 | 0.725 | 1.23 | 0.276 | 1.294 | 0.7138 | |
28 | 6 | 4.58 | 1.102 | 2.77 | 0.967 | 1.33 | 0.350 | 1.522 | 0.5151 | |
 Volixibat 10 mg | 1 | 8 | 5.44 | 0.637 | 3.04 | 0.641 | 1.86 | 0.421 | 0.875 | 0.4316 |
14 | 8 | 4.94 | 0.774 | 2.66 | 0.715 | 1.80 | 0.518 | 0.914 | 0.5547 | |
28 | 8 | 4.98 | 0.504 | 2.59 | 0.559 | 1.94 | 0.346 | 1.055 | 0.5934 | |
Patients with T2DM | ||||||||||
 Placebo | 1 | 3 | 4.60 | 0.964 | 2.83 | 0.874 | 1.07 | 0.115 | 2.260 | 1.0817 |
14 | 3 | 4.37 | 0.586 | 2.57 | 0.404 | 1.03 | 0.153 | 2.527 | 1.1007 | |
28 | 3 | 5.03 | 1.266 | 2.93 | 0.603 | 1.13 | 0.153 | 3.070 | 2.4333 | |
 Volixibat 10 mg | 1 | 8 | 4.69 | 1.037 | 3.01 | 0.926 | 1.25 | 0.245 | 1.725 | 0.5263 |
14 | 8 | 4.20 | 1.135 | 2.46 | 1.086 | 1.25 | 0.214 | 2.074 | 0.8015 | |
28 | 8 | 4.68 | 0.924 | 2.84 | 0.890 | 1.29 | 0.275 | 1.933 | 0.5337 |