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Table 2 Grade 3 or 4 toxicity according to the CTCAE (version 4)

From: Palliative chemotherapy for pancreatic adenocarcinoma: a retrospective cohort analysis of efficacy and toxicity of the FOLFIRINOX regimen focusing on the older patient

  all, n (%) <65 years ≥ 65 years
Any grade ≥ 3 toxicity 46 (52.3) 41 (56.2) 5 (33.3)
Hematological toxicity grade ≥ 3
 Neutropenia 2 (2.3) 2 (2.7) 0
 Febrile neutropenia 1 (1.1) 1 (1.4) 0
 Thrombopenia/Anemia 3 (3.4) 3 (4.1) 0
Fatigue 6 (6.8) 4 (5.5) 2 (13.3)
Nausea/Vomiting 3 (3.4) 1 (1.4) 2 (13.3)
Diarrhea 6 (6.8) 5 (6.8) 1 (6.7)
Cholangitis 6 (6.8) 5 (6.8) 1 (6.7)
Thrombosis/Pulmonary embolism 18 (20.5) 17 (23.3) 1 (6.7)
Treatment modifications due to tocixity 50 (56.8) 43 (58.9) 7 (46.7)
Permanent treatment stop due to toxicity 7 (8.0) 4 (5.5) 3 (20.0)