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Table 2 Grade 3 or 4 toxicity according to the CTCAE (version 4)

From: Palliative chemotherapy for pancreatic adenocarcinoma: a retrospective cohort analysis of efficacy and toxicity of the FOLFIRINOX regimen focusing on the older patient

 

all, n (%)

<65 years

≥ 65 years

Any grade ≥ 3 toxicity

46 (52.3)

41 (56.2)

5 (33.3)

Hematological toxicity grade ≥ 3

 Neutropenia

2 (2.3)

2 (2.7)

0

 Febrile neutropenia

1 (1.1)

1 (1.4)

0

 Thrombopenia/Anemia

3 (3.4)

3 (4.1)

0

Fatigue

6 (6.8)

4 (5.5)

2 (13.3)

Nausea/Vomiting

3 (3.4)

1 (1.4)

2 (13.3)

Diarrhea

6 (6.8)

5 (6.8)

1 (6.7)

Cholangitis

6 (6.8)

5 (6.8)

1 (6.7)

Thrombosis/Pulmonary embolism

18 (20.5)

17 (23.3)

1 (6.7)

Treatment modifications due to tocixity

50 (56.8)

43 (58.9)

7 (46.7)

Permanent treatment stop due to toxicity

7 (8.0)

4 (5.5)

3 (20.0)