all, n (%) | <65 years | ≥ 65 years | |
---|---|---|---|
Any grade ≥ 3 toxicity | 46 (52.3) | 41 (56.2) | 5 (33.3) |
Hematological toxicity grade ≥ 3 | |||
Neutropenia | 2 (2.3) | 2 (2.7) | 0 |
Febrile neutropenia | 1 (1.1) | 1 (1.4) | 0 |
Thrombopenia/Anemia | 3 (3.4) | 3 (4.1) | 0 |
Fatigue | 6 (6.8) | 4 (5.5) | 2 (13.3) |
Nausea/Vomiting | 3 (3.4) | 1 (1.4) | 2 (13.3) |
Diarrhea | 6 (6.8) | 5 (6.8) | 1 (6.7) |
Cholangitis | 6 (6.8) | 5 (6.8) | 1 (6.7) |
Thrombosis/Pulmonary embolism | 18 (20.5) | 17 (23.3) | 1 (6.7) |
Treatment modifications due to tocixity | 50 (56.8) | 43 (58.9) | 7 (46.7) |
Permanent treatment stop due to toxicity | 7 (8.0) | 4 (5.5) | 3 (20.0) |