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Table 4 Multivariate Cox porportional hazard model for clinical relapse with off-therapy HBsAg level as a time-varying variable

From: Time-varying serum gradient of hepatitis B surface antigen predicts risk of relapses after off-NA therapy

Variables Adjusted HR 95% CI P
Time-varying HBsAg level, log IU/mL 2.32 1.28, 4.21 0.005
Male sex 1.05 0.33, 3.29 0.94
EOT age, year 1.03 1.00, 1.06 0.045
EOT ALT, U/L 1.03 1.02, 1.05 <0.0001
EOT AFP, ng/mL 0.88 0.67, 1.15 0.34
EOT anti-HBe-seropositive 1.27 0.14, 11.60 0.84
Pretreatment viral DNA, log IU/mL 1.03 0.79, 1.36 0.81
Pretreatment HBeAg-positive 0.46 0.66, 3.21 0.43
Pretreatment anti-HBe-positive 0.47 0.70, 3.20 0.44
  1. Notes. AFP alpha-fetoprotein, ALT Alanine transaminase, CI confidence interval, EOT end-of-therapy, HBeAg hepatitis B e antigen, HBsAg hepatitis B surface antigen, HR hazard ratio