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Fig. 5 | BMC Gastroenterology

Fig. 5

From: Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis

Fig. 5

Alternation of the saturated fatty acids by the gut microbiota. Diagram of the current study. Upon the feeding of STHD-01, unsaturated fatty acids (FA) are metabolized to saturated FAs (SFA) by the gut microbiota. SFAs are absorbed from the intestine and accumulate in the liver. The accumulation of SFAs in the liver will promote liver inflammation. On the other hand, the depletion of the gut microbiota by antibiotics results in lower levels of SFA generation and absorption in and from the intestine. Hence, the accumulation of fat and inflammation in the liver are attenuated in the antibiotics-treated mice

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