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Table 2 Association between colorectal cancer risk and SNPs in the TAS2R16 region stratified by histology

From: Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer

SNP Alleles (Major/minor) Site Case/Controla MM vs Mmb P value MM vs mmb P value MM vs Mm+mmb P value MM + Mm vs mmb P value P trend
MM Mm mm
rs860170 A/G All 785/653 846/681 245/184 1.04(0.9–1.22) 0.57 1.05(0.83–1.32) 0.69 1.05(0.9–1.21) 0.55 1.03(0.83–1.27) 0.82 0.37
Colon 447/653 487/681 141/184 1.03(0.87–1.23) 0.73 1.07(0.82–1.4) 0.52 1.04(0.88–1.23) 0.64 1.06(0.82–1.35) 0.67 0.37
Rectum 231/653 256/681 68/184 1.06(0.85–1.32) 0.61 1.02(0.74–1.43) 0.89 1.05(0.85–1.29) 0.64 0.99(0.73–1.36) 0.97 0.65
rs978739 A/G All 830/693 777/678 182/156 0.97(0.83–1.13) 0.67 0.98(0.77–1.26) 0.89 0.97(0.84–1.12) 0.68 1(0.79–1.27) 0.99 0.65
Colon 487/693 422/678 97/156 0.9(0.75–1.07) 0.22 0.88(0.65–1.17) 0.37 0.89(0.75–1.05) 0.18 0.92(0.7–1.22) 0.58 0.18
Rectum 240/693 222/678 71/156 0.97(0.78–1.22) 0.82 1.36(0.97–1.9) 0.08 1.04(0.85–1.29) 0.68 1.37(1–1.89) 0.05 0.30
rs1357949 T/C All 927/719 761/659 180/145 0.91(0.78–1.05) 0.20 0.95(0.74–1.23) 0.71 0.91(0.79–1.06) 0.22 1(0.78–1.27) 0.99 0.31
Colon 512/719 443/659 110/145 0.97(0.81–1.15) 0.72 1.09(0.82–1.46) 0.54 0.99(0.84–1.17) 0.92 1.11(0.84–1.46) 0.46 0.98
Rectum 292/719 211/659 50/145 0.78(0.63–0.97) 0.03 0.82(0.57–1.19) 0.30 0.79(0.64–0.97) 0.02 0.92(0.65–1.32) 0.66 0.06
rs1525489 T/C All 1728/956 145/62 1/0 1.24(0.88–1.73) 0.22 - - 1.22(0.88–1.70) 0.23 - - 0.08
Colon 992/956 77/62 0/0 1.22(0.83–1.8) 0.30 - - 1.22(0.83–1.8) 0.30 - - 0.31
Rectum 505/956 53/62 1/0 1.59(1.03–2.43) 0.03 - - 1.62(1.06–2.47) 0.03 - - 0.007
rs6466849 G/A All 1276/1024 524/452 62/52 0.97(0.83–1.14) 0.75 1.01(0.68–1.51) 0.95 0.98(0.84–1.14) 0.78 1.02(0.69–1.51) 0.92 0.40
Colon 748/1024 284/452 36/52 0.88(0.73–1.05) 0.16 0.97(0.61–1.53) 0.88 0.88(0.74–1.06) 0.18 1(0.64–1.58) 0.99 0.16
Rectum 376/1024 156/452 22/52 1(0.8–1.26) 0.97 1.25(0.73–2.15) 0.42 1.03(0.83–1.28) 0.79 1.25(0.73–2.13) 0.42 0.92
rs10268496 T/G All 1200/951 596/510 100/70 0.92(0.79–1.07) 0.28 1.07(0.77–1.49) 0.70 0.94(0.81–1.08) 0.38 1.1(0.79–1.53) 0.57 0.81
Colon 678/951 342/510 62/70 0.94(0.79–1.12) 0.49 1.18(0.81–1.71) 0.39 0.97(0.82–1.15) 0.72 1.2(0.83–1.74) 0.33 0.79
Rectum 364/951 175/510 25/70 0.88(0.7–1.09) 0.24 0.86(0.53–1.41) 0.55 0.87(0.71–1.08) 0.21 0.9(0.55–1.46) 0.67 0.37
  1. aNumbers may not add up 100% to genotyping failure, covariate missing values or DNA depletion
  2. bMM vs Mm = Common homozygous carriers vs heterozygous; MM vs mm = Common homozygous vs rare homozygous; MM vs Mm + mm = Common homozygous vs heterozygous + rare homozygous (Dominant Model); MM + Mm vs mm = Common homozygous + heterozygous vs rare homozygous. Odds Ratio (95% confidence interval).All analysis are adjusted for age, gender and country of origin