Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer

Barontini, Jonathan; Antinucci, Marco; Tofanelli, Sergio; Cammalleri, Maurizio; Dal Monte, Massimo; Gemignani, Federica; Vodicka, Pavel; Marangoni, Roberto; Vodickova, Ludmila; Kupcinskas, Juozas; Vymetalkova, Veronika; Forsti, Asta; Canzian, Federico; Stein, Angelika; Moreno, Victor; Mastrodonato, Nicola; Tavano, Francesca; Panza, Anna; Barale, Roberto; Landi, Stefano; Campa, Daniele

doi:10.1186/s12876-017-0659-9

BMC Gastroenterology

Table 2 Association between colorectal cancer risk and SNPs in the TAS2R16 region stratified by histology

From: Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer

SNP	Alleles (Major/minor)	Site	Case/Control^a			MM vs Mm^b	P value	MM vs mm^b	P value	MM vs Mm+mm^b	P value	MM + Mm vs mm^b	P value	P trend
SNP	Alleles (Major/minor)	Site	MM	Mm	mm	MM vs Mm^b	P value	MM vs mm^b	P value	MM vs Mm+mm^b	P value	MM + Mm vs mm^b	P value	P trend
rs860170	A/G	All	785/653	846/681	245/184	1.04(0.9–1.22)	0.57	1.05(0.83–1.32)	0.69	1.05(0.9–1.21)	0.55	1.03(0.83–1.27)	0.82	0.37
		Colon	447/653	487/681	141/184	1.03(0.87–1.23)	0.73	1.07(0.82–1.4)	0.52	1.04(0.88–1.23)	0.64	1.06(0.82–1.35)	0.67	0.37
		Rectum	231/653	256/681	68/184	1.06(0.85–1.32)	0.61	1.02(0.74–1.43)	0.89	1.05(0.85–1.29)	0.64	0.99(0.73–1.36)	0.97	0.65
rs978739	A/G	All	830/693	777/678	182/156	0.97(0.83–1.13)	0.67	0.98(0.77–1.26)	0.89	0.97(0.84–1.12)	0.68	1(0.79–1.27)	0.99	0.65
		Colon	487/693	422/678	97/156	0.9(0.75–1.07)	0.22	0.88(0.65–1.17)	0.37	0.89(0.75–1.05)	0.18	0.92(0.7–1.22)	0.58	0.18
		Rectum	240/693	222/678	71/156	0.97(0.78–1.22)	0.82	1.36(0.97–1.9)	0.08	1.04(0.85–1.29)	0.68	1.37(1–1.89)	0.05	0.30
rs1357949	T/C	All	927/719	761/659	180/145	0.91(0.78–1.05)	0.20	0.95(0.74–1.23)	0.71	0.91(0.79–1.06)	0.22	1(0.78–1.27)	0.99	0.31
		Colon	512/719	443/659	110/145	0.97(0.81–1.15)	0.72	1.09(0.82–1.46)	0.54	0.99(0.84–1.17)	0.92	1.11(0.84–1.46)	0.46	0.98
		Rectum	292/719	211/659	50/145	0.78(0.63–0.97)	0.03	0.82(0.57–1.19)	0.30	0.79(0.64–0.97)	0.02	0.92(0.65–1.32)	0.66	0.06
rs1525489	T/C	All	1728/956	145/62	1/0	1.24(0.88–1.73)	0.22	-	-	1.22(0.88–1.70)	0.23	-	-	0.08
		Colon	992/956	77/62	0/0	1.22(0.83–1.8)	0.30	-	-	1.22(0.83–1.8)	0.30	-	-	0.31
		Rectum	505/956	53/62	1/0	1.59(1.03–2.43)	0.03	-	-	1.62(1.06–2.47)	0.03	-	-	0.007
rs6466849	G/A	All	1276/1024	524/452	62/52	0.97(0.83–1.14)	0.75	1.01(0.68–1.51)	0.95	0.98(0.84–1.14)	0.78	1.02(0.69–1.51)	0.92	0.40
		Colon	748/1024	284/452	36/52	0.88(0.73–1.05)	0.16	0.97(0.61–1.53)	0.88	0.88(0.74–1.06)	0.18	1(0.64–1.58)	0.99	0.16
		Rectum	376/1024	156/452	22/52	1(0.8–1.26)	0.97	1.25(0.73–2.15)	0.42	1.03(0.83–1.28)	0.79	1.25(0.73–2.13)	0.42	0.92
rs10268496	T/G	All	1200/951	596/510	100/70	0.92(0.79–1.07)	0.28	1.07(0.77–1.49)	0.70	0.94(0.81–1.08)	0.38	1.1(0.79–1.53)	0.57	0.81
		Colon	678/951	342/510	62/70	0.94(0.79–1.12)	0.49	1.18(0.81–1.71)	0.39	0.97(0.82–1.15)	0.72	1.2(0.83–1.74)	0.33	0.79
		Rectum	364/951	175/510	25/70	0.88(0.7–1.09)	0.24	0.86(0.53–1.41)	0.55	0.87(0.71–1.08)	0.21	0.9(0.55–1.46)	0.67	0.37

^aNumbers may not add up 100% to genotyping failure, covariate missing values or DNA depletion
^bMM vs Mm = Common homozygous carriers vs heterozygous; MM vs mm = Common homozygous vs rare homozygous; MM vs Mm + mm = Common homozygous vs heterozygous + rare homozygous (Dominant Model); MM + Mm vs mm = Common homozygous + heterozygous vs rare homozygous. Odds Ratio (95% confidence interval).All analysis are adjusted for age, gender and country of origin

Back to article page

ISSN: 1471-230X

Contact us

Submission enquiries: bmcgastroenterology@biomedcentral.com
General enquiries: ORSupport@springernature.com