Table 4 Sensitivity, specificity and AUROCs of the four different biomarkers in patients with low and high-replicative HBV at different cutoff values in identifying significant fibrosis (F2–4)
From: Diminished accuracy of biomarkers of fibrosis in low replicative chronic hepatitis B
Biomarker Cut-off | HBV DNA ≤ 20,000 IU/mL | HBV DNA ≥ 20,000 IU/mL | ||||
|---|---|---|---|---|---|---|
Sensitivity (%, 95% CI) | Specificity (%, 95% CI) | AUROC (%, 95% CI) | Sensitivity (%, 95% CI) | Specificity (%, 95% CI) | AUROC (%, 95% CI) | |
AST-Platelet Ratio Index (APRI) | AST-Platelet Ratio Index (APRI) | |||||
≥0.5 | 48.7 (32.4–65.2) | 98.0 (91.2–99.5) | 0.70 (0.63–0.77) | 69.6 (57.3–80.1) | 68.9 (57.1–79.2) | 0.69 (0.61–0.77) |
≥0.7 | 33.3 (19.1–50.2) | 98.1 (94.5–99.6) | 0.66 (0.59–0.72) | 47.8 (35.7–60.2) | 77.0 (65.8–86.0) | 0.62 (0.54–0.70) |
≥1.0 | 17.9 (7.5–33.5)a | 99.4 (96.5–100.0) | 0.59 (0.51–0.66) | 27.5 (17.5–39.6) | 91.9 (83.2–97.0) | 0.60 (0.51–0.68) |
≥1.5 | 5.1 (0.6–17.3)a | 100.0 (97.7–100.0) | 0.53 (0.45–0.60) | 13.0 (6.1–23.3)a | 95.9 (88.6–99.2) | 0.54 (0.46–0.63) |
AST/ALT Ratio (AAR) | AST/ALT Ratio (AAR) | |||||
>1.0 | 37.5 (22.7–54.2) | 84.3 (77.9–89.5) | 0.61 (0.54–0.68) | 19.4 (11.1–30.5) | 76.6 (65.6–85.5) | 0.48 (0.40–0.56) |
FIB-4 | FIB-4 | |||||
≥1.45 | 35.9 (21.2–52.8) | 97.5 (93.7–99.3) | 0.67 (0.60–0.73) | 30.4 (19.9–42.7) | 87.8 (78.2–94.3) | 0.59 (0.51–0.67) |
≥2.0 | 23.1 (11.1–39.3) | 98.7 (95.5–99.9) | 0.61 (0.54–0.68) | 23.2 (13.9–34.9) | 91.9 (83.2–97.0) | 0.58 (0.49–0.66) |
≥3.25 | 15.4 (5.9–30.5)a | 100.0 (97.7–100.0) | 0.58 (0.50–0.65) | 5.8 (1.6–14.2)a | 97.3 (90.6–99.7) | 0.52 (0.43–0.60) |
Age-Platelet Index (API) | Age-Platelet Index (API) | |||||
>4 | 37.5 (22.7–54.2) | 94.8 (90.3–97.6) | 0.66 (0.59–0.72) | 15.6 (7.7–26.9) | 93.8 (86.0–97.9) | 0.55 (0.46–0.63) |
>5 | 22.5 (10.8–38.5) | 97.1 (93.4–99.1) | 0.60 (0.53–0.66) | 16.4 (8.8–26.9) | 96.3 (89.4–99.2) | 0.56 (0.48–0.64) |
>6 | 15.0 (5.7–29.8)a | 100.0 (97.9–100.0) | 0.58 (0.51–0.64) | 8.2 (3.0–17.0)a | 98.8 (93.2–99.9) | 0.53 (0.45–0.59) |
>7 | 7.5 (1.6–20.4)a | 100.0 (97.9–100.0) | 0.54 (0.47–0.61) | 2.7 (0.3–9.6)a | 98.8 (93.2–99.9) | 0.51 (0.43–0.59) |