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Table 2 Mean scores of the four biomarkers in increasing stages (Metavir) of liver fibrosis

From: Diminished accuracy of biomarkers of fibrosis in low replicative chronic hepatitis B

Fibrosis Stage

APRI (95% CI)

P value

AAR (95% CI)

P value

FIB-4 (95% CI)

P value

API (95% CI)

P value

STAGE 0

0.32 (0.27–0.38)

< 0.0001

0.77 (0.31–0.42)

0.445

0.66 (0.54–0.78)

< 0.0001

1.58 (1.22–1.94)

< 0.0001

STAGE 1

0.38

(0.31–0.45)

0.65

(0.69–0.83)

0.71

(0.63–0.78)

1.74

(1.52–1.96)

STAGE 2

0.71

(0.52–0.90)

0.68

(0.60–0.77)

1.08

(0.88–1.29)

2.59

(2.11–3.07)

STAGE 3

0.88

(0.66–1.09)

0.86

(0.58–1.14)

1.66

(1.06–2.25)

3.56

(2.68–4.44)

STAGE 4

1.13

(0.51–1.76)

0.96

(0.68–1.24)

2.52

(1.49–3.55)

5.10

(3.93–6.27)

  1. AST aspartate aminotransferase, APRI AST-to-platelet ratio index, AAR AST/alanine aminotransferase ratio, API age-platelet index