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Fig. 1 | BMC Gastroenterology

Fig. 1

From: Diminished accuracy of biomarkers of fibrosis in low replicative chronic hepatitis B

Fig. 1

a Receiver operating characteristics curve of the best compromise sensitivity-specificity of AST (aspartate aminotransferase)-platelet ratio index (APRI), AST/alanine aminotransferase ratio (AAR), FIB-4 index and age-platelet index (API) for identifying fibrosis score F2–4 in low-replicative HBV patients. In patients meeting these cut-offs, the sensitivity for APRI (≥0.33) is 76.4% and the specificity is 74.4% (AUROC, 0.80; 95% CI: 0.73–0.85; P < 0.0001), for AAR (≥0.93) the sensitivity is 73.5% and the specificity 47.5% (AUROC, 0.62; 95% CI: 0.55–0.69; P = 0.023), for FIB-4 (≥0.70) the sensitivity is 72.9% and specificity is 76.9% (AUROC, 0.81; 95% CI: 0.75–0.86; P < 0.0001), and for API (>2) the sensitivity is 75.1% and specificity is 55.0% (AUROC, 0.71; 95% CI: 0.64–0.77; P < 0.0001). b Receiver operating characteristics curve of the best compromise sensitivity-specificity of AST (aspartate aminotransferase)-platelet ratio index (APRI), AST/alanine aminotransferase ratio (AAR), FIB-4 index and age-platelet index (API) for identifying fibrosis score F2–4 in high-replicative HBV patients. In patients meeting these cut-offs, the sensitivity for APRI (≥0.33) is 52.7% and the specificity is 87.0% (AUROC, 0.73; 95% CI: 0.65–0.80; P < 0.0001), for AAR (≥0.91) the sensitivity is 24.7% and the specificity 79.2% (AUROC, 0.52; 95% CI: 0.44–0.60; P = 0.643), for FIB-4 (≥0.70) the sensitivity is 58.1% and specificity is 66.7% (AUROC, 0.67; 95% CI: 0.59–0.75; P = 0.0001), and for API (>2) the sensitivity is 75.0% and specificity is 56.2% (AUROC, 0.69; 95% CI: 0.61–0.76; P < 0.0001)

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