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Table 3 Prognostic factors in patients with metastatic HCC treated with TACE or TACE and sorafenib in combination

From: Survival benefit of transarterial chemoembolization in patients with metastatic hepatocellular carcinoma: a single center experience

Parameters

Univariate

Multivariate

HR1

95% CI2

p

HR

95% CI

p

Age

1.01

0.98 – 1.04

0.725

   

gender (male vs. female)

2.27

1.00 – 5.11

0.048

2.39

0.99 – 5.76

0.052

Intrahepatic tumor expansion (multifocal vs. oligododular)

1.95

1.07 – 3.55

0.028

1.86

0.99 – 3.47

0.031

Tumor size (cm)

1.02

0.95 - 1.10

0.527

   

Sorafenib

0.89

0.51 – 1.56

0.688

   

ALBI

  

0.769

   

 ALBI 1

1

     

 ALBI 2

1.24

0.69 – 2.24

0.468

   

 ALBI 3

1.16

0.46 – 2.94

0.761

   

viral vs. non-viral etiology

1.03

0.60 – 1.76

0.923

   

segmental portal vein thrombosis

2.10

1.04 – 4.24

0.038

   

AFP > 400 ng/ml

1.16

0.68 - 2.00

0.582

   

ECOG

      

 0

1

     

 1

0.91

0.43 – 1.95

    

 2

2.60

0.91 7.48

    

multiple metastases

0.99

0.48 – 2.04

0.981

   
  1. Additional sorafenib treatment in patients with metastatic HCC treated with TACE did not result in an independent positive prognostic effect. BCLC was not entered in the Cox model as all patients were classified as BLCL C who were treated with TACE or TACE and sorafenib
  2. Abbreviations: 1 HR hazard ratio, 2 95% CI 95% confidence interval