Table 3 Characteristics of ALT responders and non-responders before and after glutathione treatment
|  | ALT responders (n = 15) | ALT non-responders (n = 14) | ||||
|---|---|---|---|---|---|---|
Before treatment | After treatment | P-value | Before treatment | After treatment | P-value | |
Age (year) | 50.7 ± 12.1 | - | 61.7 ± 12.4 | - | ||
Male/female (n) | 9 (6) | - | 5 (9) | - | ||
Dyslipidemia (%) | 12 (80.0) | - | 12 (85.7) | - | ||
Statin (%) | 4 (26.7) | - | 8 (57.1) | - | ||
Diabetes (%) | 5 (33.3) | - | 9 (64.3) | - | ||
BMI (kg/m2) | 26.5 ± 4.1 | 26.5 ± 4.0 | 0.23 | 26.6 ± 3.8 | 26.4 ± 3.9 | 0.45 |
FBS (mg/dL) | 115.7 ± 37.9 | 113.0 ± 23.0 | 0.38 | 121.4 ± 31.2 | 128.2 ± 31.4 | 0.004 |
IRI (μU/mL) | 23.5 ± 22.7 | 17.9 ± 14.3 | 0.14 | 22.6 ± 38.0 | 30.5 ± 31.4 | 0.11 |
HbA1c (%) | 5.94 ± 1.03 | 6.08 ± 1.10 | 0.017 | 6.9 ± 1.2 | 6.89 ± 1.28 | 0.14 |
HDL cholesterol (mg/dL) | 60.3 ± 18.6 | 57.4 ± 16.7 | 0.001 | 49.7 ± 11.7 | 52.2 ± 13.8 | 0.08 |
LDL cholesterol (mg/dL) | 124.5 ± 33.1 | 117.1 ± 34.8 | 0.06 | 102.9 ± 18.6 | 104.1 ± 14.5 | 0.41 |
Triglycerides (mg/dL) | 202.4 ± 164.1 | 178.8 ± 157.6 | 0.15 | 187.6 ± 103.3 | 146.2 ± 62.1 | 0.003 |
NEFA (μEq/L) | 720.2 ± 285.0 | 576.0 ± 230.1 | 0.032 | 563.3 ± 143.0 | 473.9 ± 170.7 | 0.13 |
AST (IU/L) | 46.3 ± 20.2 | 40.0 ± 20.7 | 0.11 | 47.1 ± 14.1 | 55.8 ± 19.3 | 0.003 |
ALT (IU/L) | 77.1 ± 38.6 | 47.9 ± 28.1 | <0.0001 | 60.1 ± 32.2 | 68.9 ± 36.3 | 0.005 |
GGT (IU/L) | 81.9 ± 58.0 | 64.8 ± 48.4 | 0.07 | 58.0 ± 26.6 | 68.5 ± 48.3 | 0.06 |
Ferritin (ng/mL) | 260.2 ± 164.5 | 217.7 ± 162.3 | 0.015 | 176.6 ± 126.1 | 169.5 ± 109.9 | 0.28 |
Platelet count (×104 /μL) | 20.3 ± 4.6 | 20.2 ± 4.7 | 0.45 | 21.3 ± 6.8 | 21.8 ± 6.0 | 0.25 |
Type IV collagen 7 s | 4.61 ± 1.13 | 4.39 ± 1.06 | 0.10 | 5.59 ± 2.51 | 5.42 ± 1.49 | 0.13 |
Glutathione in protein fraction (μM) | 1.53 ± 0.92 | 0.88 ± 0.53 | 0.004 | 1.27 ± 0.83 | 1.00 ± 0.77 | 0.24 |
Glutathione in deprotenized fraction (μM) | 0.017 ± 0.020 | 0.019 ± 0.029 | 0.60 | 0.036 ± 0.057 | 0.018 ± 0.017 | 0.19 |
CAP (db/m) | 300.3 ± 41.1 | 285.1 ± 53.2 | 0.049 | 290.4 ± 50.2 | 285.8 ± 44.9 | 0.31 |
LSM (kPa) | 8.71 ± 4.63 | 7.91 ± 4.22 | 0.19 | 11.36 ± 5.05 | 10.9 ± 4.38 | 0.32 |