| |
ALT responders (n = 15)
|
ALT non-responders (n = 14)
|
P-value
|
|---|
|
Age (year)
|
50.7 ± 12.1
|
61.7 ± 12.4
|
0.011
|
|
Male/female (n)
|
9 (6)
|
5 (9)
|
0.191
|
|
Dyslipidemia (%)
|
12 (80.0)
|
12 (85.7)
|
0.68
|
|
Statin (%)
|
4 (26.7)
|
8 (57.1)
|
0.10
|
|
Diabetes (%)
|
5 (33.3)
|
9 (64.3)
|
0.10
|
|
BMI (kg/m2)
|
26.5 ± 4.1
|
26.6 ± 3.8
|
0.47
|
|
FBS (mg/dL)
|
115.7 ± 37.9
|
121.4 ± 31.2
|
0.33
|
|
IRI (μU/mL)
|
23.5 ± 22.7
|
22.6 ± 38.0
|
0.47
|
|
HbA1c (%)
|
5.94 ± 1.03
|
6.9 ± 1.2
|
0.019
|
|
HDL cholesterol (mg/dL)
|
60.3 ± 18.6
|
49.7 ± 11.7
|
0.04
|
|
LDL cholesterol (mg/dL)
|
124.5 ± 33.1
|
102.9 ± 18.6
|
0.021
|
|
Triglycerides (mg/dL)
|
202.4 ± 164.1
|
187.6 ± 103.3
|
0.39
|
|
NEFA (μEq/L)
|
720.2 ± 285.0
|
563.3 ± 143.0
|
0.055
|
|
AST (IU/L)
|
46.3 ± 20.2
|
47.1 ± 14.1
|
0.45
|
|
ALT (IU/L)
|
77.1 ± 38.6
|
60.1 ± 32.2
|
0.104
|
|
GGT (IU/L)
|
81.9 ± 58.0
|
58.0 ± 26.6
|
0.085
|
|
Ferritin (ng/mL)
|
260.2 ± 164.5
|
176.6 ± 126.1
|
0.07
|
|
Platelet count (×104 /μL)
|
20.3 ± 4.6
|
21.3 ± 6.8
|
0.32
|
|
Type IV collagen 7 s
|
4.61 ± 1.13
|
5.59 ± 2.51
|
0.09
|
|
Glutathione in protein fraction (μM)
|
1.53 ± 0.92
|
1.27 ± 0.83
|
0.230
|
|
Glutathione in deprotenized fraction (μM)
|
0.017 ± 0.020
|
0.036 ± 0.057
|
0.116
|
|
CAP (db/m)
|
300.3 ± 41.1
|
290.4 ± 50.2
|
0.29
|
|
LSM (kPa)
|
8.71 ± 4.63
|
11.36 ± 5.05
|
0.080
|
- Data are expressed as mean ± standard deviation
-
Abbreviations: BMI body mass index, FBS fasting blood sugar, IRI immunoreactive insulin, HBA1c hemoglobin A1c, HDL cholesterol high density lipoprotein cholesterol, LDL cholesterol low density lipoprotein cholesterol, NEFA non-esterified fatty acid, AST asparate aminotransferase, ALT alanine aminotransferase, GGT γ-glutamyl transpeptidase, CAP controlled attenuation parameter, LSM liver stiffness measurement
