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Fig. 7 | BMC Gastroenterology

Fig. 7

From: Anti-fibrogenic effect of PPAR-γ agonists in human intestinal myofibroblasts

Fig. 7

A proposed model showing the mechanism of action of PPAR-γ agonists (TRG and RSG) on TGF-β1-induced fibrogenic activation in human primary intestinal myofibroblasts. TGF-β1 induces expression of Procol1A1, FN, and α-SMA by activating the PI3K/Akt pathway and Smad2. PPARγ agonists (TRG and RSG) inhibit TGF-β-induced fibrogenic responses by blocking Akt signaling and Smad2 phosphorylation

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