Fig. 7
From: Anti-fibrogenic effect of PPAR-γ agonists in human intestinal myofibroblasts
A proposed model showing the mechanism of action of PPAR-γ agonists (TRG and RSG) on TGF-β1-induced fibrogenic activation in human primary intestinal myofibroblasts. TGF-β1 induces expression of Procol1A1, FN, and α-SMA by activating the PI3K/Akt pathway and Smad2. PPARγ agonists (TRG and RSG) inhibit TGF-β-induced fibrogenic responses by blocking Akt signaling and Smad2 phosphorylation