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Table 4 For genes with a significant genetic association to IBD, CD, or UC, gene expression (ΔCt values) was analyzed in relation to presence of inflammation, using logistic regression. ΔCt values are inversely related to gene expression values. The estimates represent the natural logarithm of the odds ratio with a negative value corresponding to increased odds for inflammation, while a positive value corresponds to decreased odds

From: Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease

Gene expression

Single logistic regression

p value

Estimate

Estimate (95% CI)

Nagelkerke R2

IBD; colonic biopsies a

F11R

0.139

1.04

-0.34–2.43

0.05

MAGI2

0.115

0.93

-0.22–2.08

0.06

MAGI3

1.53×10-4

3.38

1.63–5.13

0.52

PTEN

6.72×10-5

10.25

5.21–15.29

0.69

PTPN22

0.005

-1.76

-2.98– -0.54

0.22

TJP1

1.56×10-4

4.97

2.39–7.55

0.48

CD; ileal biopsies b

F11R

0.768

0.34

-1.92–2.61

0.01

MAGI2

0.065

-2.48

-5.11–0.15

0.35

MAGI3

0.107

1.97

-0.43–4.36

0.28

PTEN

0.343

3.35

-3.58–10.27

0.08

PTPN22

0.388

0.56

-0.71–1.82

0.06

TJP1

0.230

2.07

-1.84–5.97

0.09

CD; colonic biopsies c

F11R

0.357

1.30

-1.47–4.06

0.06

MAGI2

0.118

1.94

-0.49–4.38

0.21

MAGI3

0.047

3.01

0.03–5.98

0.39

PTEN

e

e

e

e

PTPN22

0.029

-2.82

-5.35– -0.29

0.45

TJP1

0.028

5.13

0.56-9.69

0.50

UC; colonic biopsies d

F11R

0.408

0.70

-0.96–2.35

0.03

MAGI2

0.684

0.30

-1.16–1.77

0.01

MAGI3

0.003

3.39

1.19–5.59

0.55

PTEN

0.002

7.95

2.82–13.08

0.57

PTPN22

0.048

-1.54

-3.06– -0.01

0.18

TJP1

0.003

4.83

1.61-8.05

0.47

  1. IBD inflammatory bowel disease, CD Crohn’s disease, UC ulcerative colitis
  2. annon-inflamed=29 and ninflamed=28. bnnon-inflamed=11 and ninflamed=6. cnnon-inflamed=12 and ninflamed=7. dnnon-inflamed=16 and ninflamed=19. eComplete separation and thereby uncertain data (Mann-Whitney U-test showed decreased gene expression level in inflamed mucosa, compared to non-inflamed mucosa; p=0.0004)