Skip to main content

Table 3 For genes with a significant genetic association to IBD, CD, or UC, gene expression (ΔCt values) was analyzed in relation to genotype, in intestinal biopsies from the different subgroups, using Spearman’s rank correlation test

From: Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease

  

Non-IBD

Non-inflamed IBD

Inflamed IBD

Gene

Gene SNPa

Ileum

Colon

Ileum

Colon

Ileum

Colon

  

p-valueb

p-valueb

p-valueb

p-valueb

p-valueb

p-valueb

F11R

rs7546890 (T)

0.144 (5, 14, 5)

0.112 (6, 19, 8)

0.167 (5, 13, 6)

0.541 (8, 15, 6)

0.140 (1, 4, 1)

0.347 (7, 16, 5)

MAGI2

rs7803276 (C)

0.009 (10, 8, 6)

0.603 (11, 15, 7)

0.604 (5, 11, 8)

0.029 (8, 14, 7)

0.637 (3, 2, 1)

0.285 (6, 13, 9)

rs6962966 (A)

0.797 (11, 8, 5)

0.657 (14, 11, 8)

0.266 (5, 11, 8)

0.868 (6, 16, 7)

0.954 (3, 1, 2)

0.817 (6, 13, 9)

MAGI3

rs6689879 (C)

0.002 (4, 7, 13)

0.050 (5, 10, 18)

0.497 (1, 8, 15)

0.785 (2, 13, 14)

0.021 (0, 3, 3)

0.355 (1, 13, 14)

rs1343126 (T)

1.000 (0, 14, 10)

0.916 (0, 16, 17)

0.044 (1, 15, 8)

0.737 (2, 14, 13)

0.594 (1, 3, 2)

0.780 (0, 18, 10)

rs12119076 (C)

0.978 (0, 13, 11)

0.777 (0, 15, 18)

0.044 (1, 15, 8)

0.737 (2, 14, 13)

0.594 (1, 3, 2)

0.780 (0, 18, 10)

rs6679677d

0.266 (18, 6, 0)

0.018 (25, 8, 0)

0.477 (22, 2, 0)

0.834 (26, 3, 0)

NAc (6, 0, 0)

0.047 (25, 3, 0)

PTEN

rs1234224 (G)

0.554 (2, 12, 10)

0.458 (3, 16, 14)

0.851 (1, 9, 14)

0.772 (2, 15, 12)

NAc (0, 0, 6)

0.695 (3, 14, 11)

PTPN22

rs6689879 (C)

0.697 (4, 7, 13)

0.509 (5, 10, 18)

0.634 (1, 8, 15)

0.129 (2, 13, 14)

0.854 (0, 3, 3)

0.764 (1, 13, 14)

rs1343126 (T)

0.227 (0, 14, 10)

0.025 (0, 16, 17)

0.870 (1, 15, 8)

0.822 (2, 14, 13)

0.908 (1, 3, 2)

0.963 (0, 18, 10)

rs12119076 (C)

0.555 (0, 13, 11)

0.089 (0, 15, 18)

0.870 (1, 15, 8)

0.822 (2, 14, 13)

0.908 (1, 3, 2)

0.963 (0, 18, 10)

rs6679677d

0.128 (18, 6, 0)

0.183 (25, 8, 0)

0.147 (22, 2, 0)

0.291 (26, 3, 0)

NAc (6, 0, 0)

0.745 (25, 3, 0)

TJP1

rs260526 (G)

0.285 (21, 3, 0)

0.052 (29, 4, 0)

0.582 (21, 3, 0)

0.396 (24, 5, 0)

NAc (6, 0, 0)

0.517 (22, 5, 1)

  1. IBD inflammatory bowel disease, CD Crohn’s disease, UC ulcerative colitis
  2. aThe susceptibility allele is shown in parentheses. bNumber of individuals in each genotype group is shown in parentheses (individuals homozygous for the susceptibility allele, heterozygous individuals, and individuals homozygous for the non-susceptibility allele). cNA; not applicable. dThe susceptibility allele (C) is defined from Jostins et. al [5]
Back to article page

BMC Gastroenterology

ISSN: 1471-230X

Contact us