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Table 2 Low serum LL-37 levels indicate an elevated relative risk of the presence of intestinal strictures in CD patients.

From: Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohn’s disease, and clinical prognosis in inflammatory bowel disease

A

B

LL-37 below 40 ng/ml

 

CRP 0.5 mg/ml or above

 

cases w ith stricture

13

cases w ith stricture

16

cases w ithout stricture

15

cases w ithout stricture

25

LL-37 40 ng/ml or above

 

CRP 0.4 mg/L or below

 

cases w ith stricture

17

cases w ith stricture

14

cases w ithout stricture

48

cases w ithout stricture

38

Relative risk

1.7752

Relative risk

1.4495

low er 95% CI

1.0

low er 95% CI

0.8

upper 95% CI

3.1

upper 95% CI

2.6

p-value

0.0485

p-value

0.2167

 

significant

 

not significant

C

test positive

LL-37 below 40 ng/ml

test negative

any others

 

mean

(95% CI interval)

prevalence

0.32

0.23

0.43

sensitivity

0.43

0.26

0.62

specificity

0.76

0.64

0.86

PPV

0.46

0.28

0.66

NPV

0.74

0.61

0.84

  1. (A) The relative risk of the low LL-37 group with the presence of stricture among CD patients. (B) The relative risk of high CRP group with the presence of stricture among CD patients. (C) Prevalence, sensitivity, specificity, PPV, and NPV values of LL-37 test in indicating the presence of stricture
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BMC Gastroenterology

ISSN: 1471-230X

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