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Table 3 Diagnostic accuracy of the noninvasive parameters of liver steatosis in the studied population using the imperfect gold standard methodology

From: Noninvasive assessment of liver steatosis in children: the clinical value of controlled attenuation parameter

Parameter

Sensitivity

(95% CI)

Specificity

(95% CI)

PPV

(95% CI)

NPV

(95% CI)

Performance a

Analysis with the imperfect gold standard methodology: scenario 1

 dCAP

0.72

(0.64–0.79)

0.98

(0.97–0.98)

0.93

(0.90–0.96)

0.89

(0.86–0.92)

0.70

 Ultrasound

0.46

(0.42–0.50)

0.91

(0.89–0.92)

0.68

(0.62–0.73)

0.80

(0.78–0.81)

0.37

 Fatty Liver index

0.73

(0.72–0.74)

0.27

(0.25–0.28)

0.30

(0.29–0.31)

0.7

(0.69–0.7)

0

 BMI + AST and/or ALT

0.75

(0.73–0.77)

0.57

(0.55–0.60)

0.43

(0.41–0.45)

0.84

(0.82–0.86)

0.22

Analysis with the imperfect gold standard methodology: scenario 2

 dCAP

0.72

(0.69–0.78)

1.00

(1.00–1.00)

0.99 (0.99–1)

0.89

(0.88–0.91)

0.72

 Ultrasound

0.43

(0.38–0.50)

0.99

(0.99–1.00)

0.96

(0.94–0.98)

0.8

(0.78–0.82)

0.42

 Hepatic Steatosis Index

0.85

(0.84–0.85)

0.33

(0.32–0.35)

0.35

(0.34–0.36)

0.83

(0.82–0.84)

0.18

 BMI + AST and/or ALT

0.73

(0.69–0.77)

0.73

(0.69–0.77)

0.54

(0.49–0.58)

0.86

(0.84–0.88)

0.54

  1. PPV positive predictive value; NPV negative predictive value; CI 95% Credible Interval; dCAP dichotomized controlled attenuation parameter; BMI body mass index; AST aspartate aminotransferase; ALT alanine aminotransferase
  2. a Performance = Sensitivity + Specificity - 100