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Table 4 Performance of DHCR7 rs12785878 polymorphism, liver fibrosis, and rapid virologic response for predicting sustained virologic response in hepatitis C virus genotype 1-infected patients

From: Vitamin D-related gene polymorphism predict treatment response to pegylated interferon-based therapy in Thai chronic hepatitis C patients

 

Sensitivity

Specificity

PPV

NPV

DHCR7 rs12785878 GG/TT

37%

76.6%

59.7%

56.6%

Liver fibrosis stage 0–1

81%

47.6%

66%

66.7%

RVR

64.9%

68.6%

69.8%

63.6%

DHCR7 rs12785878 GT/TT and RVR

18.1%

95.9%

81%

54.7%

DHCR7 rs12785878 GT/TT and liver fibrosis stage 0–1

18.4%

97.9%

88.9%

57.2%

  1. PPV positive predictive value, NPV negative predictive value, RVR rapid virologic response