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Table 4 Performance of DHCR7 rs12785878 polymorphism, liver fibrosis, and rapid virologic response for predicting sustained virologic response in hepatitis C virus genotype 1-infected patients

From: Vitamin D-related gene polymorphism predict treatment response to pegylated interferon-based therapy in Thai chronic hepatitis C patients

  Sensitivity Specificity PPV NPV
DHCR7 rs12785878 GG/TT 37% 76.6% 59.7% 56.6%
Liver fibrosis stage 0–1 81% 47.6% 66% 66.7%
RVR 64.9% 68.6% 69.8% 63.6%
DHCR7 rs12785878 GT/TT and RVR 18.1% 95.9% 81% 54.7%
DHCR7 rs12785878 GT/TT and liver fibrosis stage 0–1 18.4% 97.9% 88.9% 57.2%
  1. PPV positive predictive value, NPV negative predictive value, RVR rapid virologic response