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Table 4 Factors associated with deterioration of renal functiona (n = 533)

From: Proteinuria and baseline renal function predict mortality and renal outcomes after sirolimus therapy in liver transplantation recipients

Variable Baseline eGFR < 60 mL/min/1.73 m2 Baseline eGFR ≥ 60 mL/min/1.73 m2
  Adjusted HR (95%CI) P value Adjusted HR (95%CI) P value
Age at initiation, year
 50-64 vs 17-49 0.77 (0.29 − 2.05) 0.60 1.14 (0.66 − 1.95) 0.64
 ≥65 vs 17-49 1.08 (0.23 − 5.13) 0.92 1.20 (0.45 − 3.16) 0.72
Male vs female patients 0.82 (0.36 − 1.84) 0.61 0.35 (0.19 − 0.65) 0.001
Prior hepatitis B 0.48 (0.21 − 1.09) 0.08 0.83 (0.45 − 1.55) 0.56
Prior hepatitis C 1.43 (0.61 − 3.37) 0.40 0.93 (0.51 − 1.69) 0.80
Prior alcoholism 1.52 (0.61 − 3.77) 0.37 1.35 (0.72 − 2.54) 0.35
Prior decompensated liver cirrhosis 1.04 (0.50 − 2.17) 0.92 1.55 (0.97 − 2.46) 0.07
Prior HCC 0.66 (0.32 − 1.39) 0.28 1.85 (1.03 − 3.29) 0.04
Prior diabetes mellitus 0.95 (0.43 − 2.09) 0.89 1.20 (0.71 − 2.01) 0.50
New onset diabetes mellitus 1.47 (0.69 − 3.16) 0.32 0.63 (0.40 − 1.24) 0.23
Proteinuria at baseline 1.93 (0.87 − 4.29) 0.11 1.29 (0.70 − 2.39) 0.42
New onset proteinuria < 1 year 5.38 (2.49 − 11.62) <.0001 3.12 (1.92 − 5.09) <.0001
  1. aEvent of renal function reduction was either eGFR declined > 50%, start receiving chronic dialysis or renal transplantation; whichever comes first