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Table 3 Factors associated with new onset proteinuriaa (n = 455)

From: Proteinuria and baseline renal function predict mortality and renal outcomes after sirolimus therapy in liver transplantation recipients

  Crude Adjusted
Variable HR (95%CI) P value HR (95%CI) P value
Age at initiation, year
 50-64 vs 17-49 1.16 (0.76 − 1.75) 0.04 1.05 (0.68 − 1.62) 0.84
 ≥65 vs 17-49 2.22 (1.19 − 4.15) 0.04 1.75 (0.90 − 3.39) 0.10
Male vs female patients 0.61 (0.42 − 0.90) 0.02 0.67 (0.42 − 1.06) 0.09
Baseline eGFR < 60 vs ≥60 mL/min/1.73 m2 1.62 (1.15 − 2.27) 0.006 1.28 (0.89 − 1.85) 0.18
Hepatitis B 1.02 (0.72 − 1.44) 0.63 1.23 (0.78 − 1.95) 0.37
Hepatitis C 1.30 (0.90 − 1.87) 0.02 1.26 (0.80 − 1.97) 0.32
Alcoholism 0.64 (0.36 − 1.14) 0.74 0.79 (0.42 − 1.47) 0.45
Decompensated liver cirrhosis 1.24 (0.89 − 1.74) 0.20 1.21 (0.84 − 1.74) 0.32
HCC 1.02 (0.73 − 1.44) 0.29 1.06 (0.72 − 1.57) 0.76
Diabetes mellitus 2.32 (1.64 − 3.28) <.0001 1.91 (1.32 − 2.77) <.001
New onset diabetes mellitusb 2.77 (1.96 − 3.90) <.0001 2.34 (1.62 − 3.38) <.0001
CNI prior use 2.30 (0.73 − 7.27) 0.15 2.27 (0.69 − 7.43) 0.18
CNI use after 0.69 (0.32 − 1.48) 0.33 0.67 (0.29 − 1.54) 0.35
SRL trough level < 3 months 0.97 (0.91 − 1.03) 0.30 1.01 (0.95 − 1.07) 0.81
  1. aEvent of new onset proteinuria was identified within 1 year during the follow-up among a subgroup of patients without proteinuria presence at baseline
  2. bNew onset diabetes mellitus anytime in the follow-up period