Skip to main content

Table 7 Univariate Cox regression analyses

From: Comparison of five tumor regression grading systems for gastric adenocarcinoma after neoadjuvant chemotherapy: a retrospective study of 192 cases from National Cancer Center in China

Characteristics

OS

PFS

HR

95% CI

P value

HR

95% CI

P value

Gender

 Male (reference)

1

  

1

  

 Female

1.179

0.740–1.876

0.488

1.309

0.859–1.994

0.211

Age

 < 55y (reference)

1

  

1

  

 ≥ 55y

1.120

0.903–1.390

0.303

0.856

0.577–1.270

0.441

Location

 Esophagogastric junction (reference)

1

  

1

  

 Proximal gastric

0.952

0.555–1.632

0.857

0.829

0.506–1.358

0.456

 Distal gastric

0.634

0.360–1.117

0.115

0.631

0.380–1.046

0.074

Maximal diameter of tumor bed

1.712

1.275–2.299

<0.001

1.709

1.304–2.239

<0.001

Histological differentiation

3.057

1.617–5.782

0.001

2.667

1.513–4.699

0.001

Laurén classification

 Intestinal (reference)

1

  

1

  

 Diffuse

2.228

1.339–3.709

0.002

1.896

1.199–2.999

0.006

 Mixed

2.206

1.216–4.003

0.009

1.911

1.113–3.280

0.019

LVI

3.318

2.089–5.270

<0.001

3.324

2.180–5.069

<0.001

PNI

2.878

1.750–4.733

<0.001

2.724

1.737–4.271

<0.001

AJCC ypT category

1.876

1.457–2.415

<0.001

1.739

1.396–2.168

<0.001

AJCC ypN category

1.946

1.572–2.408

<0.001

1.918

1.578–2.330

<0.001

AJCC stage

2.484

1.724–3.580

<0.001

2.270

1.650–3.122

<0.001

Mandard-TRG

 1 (reference)

1

  

1

  

 2

0.98

0.244–3.929

0.977

1.293

0.343–4.877

0.704

 3

1.956

0.568–6.730

0.287

2.143

0.631–7.283

0.222

 4

2.717

0.836–8.831

0.096

3.155

0.979–10.168

0.054

 5

3.682

1.094–12.394

0.035

4.570

1.380–15.132

0.013

JGCA-TRG

 3 (reference)

1

  

1

  

 2

1.531

0.457–5.126

0.49

1.782

0.539–5.892

0.344

 1b

2.626

0.781–8.831

0.119

2.621

0.786–8.738

0.117

 1a

2.875

0.836–9.884

0.094

4.022

1.199–13.491

0.024

 0

3.676

1.092–12.371

0.035

4.556

1.376–15.085

0.013

CAP-TRG

 0 (reference)

1

  

1

  

 1

0.979

0.244–3.927

0.977

1.292

0.343–4.873

0.705

 2

1.953

0.568–6.719

0.288

2.140

0.630–7.272

0.223

 3

2.996

0.937–9.586

0.064

3.558

1.119–11.311

0.032

China-TRG

 Severe response (reference)

1

  

1

  

 Moderate response

1.719

0.808–3.657

0.160

1.661

0.834–3.308

0.149

 Mild response

2.856

1.450–5.628

0.002

2.868

1.544–5.328

0.001

Becker-TRG

 1a (reference)

1

  

1

  

 1b

0.980

0.244–3.927

0.977

1.292

0.343–4.872

0.705

 2

2.216

0.673–7.294

0.190

2.295

0.702–7.502

0.169

 3

3.109

0.964–10.028

0.058

3.964

1.239–12.681

0.020

R0 resection

 Yes (reference)

1

  

1

  

 No

3.382

2.022–5.659

<0.001

3.656

2.315–5.774

<0.001

Adjuvant chemotherapy

 Not received (reference)

1

  

1

  

 Received

1.040

0.633–1.707

0.878

1.227

0.774–1.943

0.384