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Table 7 Univariate Cox regression analyses

From: Comparison of five tumor regression grading systems for gastric adenocarcinoma after neoadjuvant chemotherapy: a retrospective study of 192 cases from National Cancer Center in China

Characteristics OS PFS
HR 95% CI P value HR 95% CI P value
Gender
 Male (reference) 1    1   
 Female 1.179 0.740–1.876 0.488 1.309 0.859–1.994 0.211
Age
 < 55y (reference) 1    1   
 ≥ 55y 1.120 0.903–1.390 0.303 0.856 0.577–1.270 0.441
Location
 Esophagogastric junction (reference) 1    1   
 Proximal gastric 0.952 0.555–1.632 0.857 0.829 0.506–1.358 0.456
 Distal gastric 0.634 0.360–1.117 0.115 0.631 0.380–1.046 0.074
Maximal diameter of tumor bed 1.712 1.275–2.299 <0.001 1.709 1.304–2.239 <0.001
Histological differentiation 3.057 1.617–5.782 0.001 2.667 1.513–4.699 0.001
Laurén classification
 Intestinal (reference) 1    1   
 Diffuse 2.228 1.339–3.709 0.002 1.896 1.199–2.999 0.006
 Mixed 2.206 1.216–4.003 0.009 1.911 1.113–3.280 0.019
LVI 3.318 2.089–5.270 <0.001 3.324 2.180–5.069 <0.001
PNI 2.878 1.750–4.733 <0.001 2.724 1.737–4.271 <0.001
AJCC ypT category 1.876 1.457–2.415 <0.001 1.739 1.396–2.168 <0.001
AJCC ypN category 1.946 1.572–2.408 <0.001 1.918 1.578–2.330 <0.001
AJCC stage 2.484 1.724–3.580 <0.001 2.270 1.650–3.122 <0.001
Mandard-TRG
 1 (reference) 1    1   
 2 0.98 0.244–3.929 0.977 1.293 0.343–4.877 0.704
 3 1.956 0.568–6.730 0.287 2.143 0.631–7.283 0.222
 4 2.717 0.836–8.831 0.096 3.155 0.979–10.168 0.054
 5 3.682 1.094–12.394 0.035 4.570 1.380–15.132 0.013
JGCA-TRG
 3 (reference) 1    1   
 2 1.531 0.457–5.126 0.49 1.782 0.539–5.892 0.344
 1b 2.626 0.781–8.831 0.119 2.621 0.786–8.738 0.117
 1a 2.875 0.836–9.884 0.094 4.022 1.199–13.491 0.024
 0 3.676 1.092–12.371 0.035 4.556 1.376–15.085 0.013
CAP-TRG
 0 (reference) 1    1   
 1 0.979 0.244–3.927 0.977 1.292 0.343–4.873 0.705
 2 1.953 0.568–6.719 0.288 2.140 0.630–7.272 0.223
 3 2.996 0.937–9.586 0.064 3.558 1.119–11.311 0.032
China-TRG
 Severe response (reference) 1    1   
 Moderate response 1.719 0.808–3.657 0.160 1.661 0.834–3.308 0.149
 Mild response 2.856 1.450–5.628 0.002 2.868 1.544–5.328 0.001
Becker-TRG
 1a (reference) 1    1   
 1b 0.980 0.244–3.927 0.977 1.292 0.343–4.872 0.705
 2 2.216 0.673–7.294 0.190 2.295 0.702–7.502 0.169
 3 3.109 0.964–10.028 0.058 3.964 1.239–12.681 0.020
R0 resection
 Yes (reference) 1    1   
 No 3.382 2.022–5.659 <0.001 3.656 2.315–5.774 <0.001
Adjuvant chemotherapy
 Not received (reference) 1    1   
 Received 1.040 0.633–1.707 0.878 1.227 0.774–1.943 0.384