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Table 6 Relationships between clinicopathological characteristics and pathological response evaluated by Becker-TRG system

From: Comparison of five tumor regression grading systems for gastric adenocarcinoma after neoadjuvant chemotherapy: a retrospective study of 192 cases from National Cancer Center in China

Characteristics

Total cases (n = 192), no. (%)

Becker-TRG

P value

1a (n = 11), no. (%)

1b (n = 23), no. (%)

2 (n = 67), no. (%)

3 (n = 91), no. (%)

Gender

     

0.142

 Male

139 (72.4)

10 (7.2)

20 (14.4)

45 (32.4)

64 (46)

 

 Female

53 (27.6)

1 (1.9)

3 (5.7)

22 (41.5)

27 (50.9)

 

Age

     

0.945

 < 55y

89 (46.4)

6 (6.7)

10 (11.2)

31 (34.8)

42 (47.2)

 

 ≥ 55y

103 (53.6)

5 (4.9)

13 (12.6)

36 (35)

49 (47.6)

 

Location

     

0.562

 Esophagogastric junction

44 (22.9)

1 (2.3)

4 (9.1)

15 (34.1)

24 (54.5)

 

 Proximal gastric

71 (37)

7 (9.9)

8 (11.3)

24 (33.8)

32 (45.1)

 

 Distal gastric

77 (40.1)

3 (3.9)

11 (14.3)

28 (36.4)

35 (45.5)

 

Maximal diameter of tumor bed

     

0.003

 < 4.5 cm

108 (56.2)

9 (8.3)

20 (18.5)

35 (32.4)

44 (40.7)

 

 4.5–8 cm

64 (33.3)

1 (1.6)

3 (4.7)

28 (43.8)

32 (50)

 

 > 8 cm

20 (10.4)

1 (5)

0 (0)

4 (20)

15 (75)

 

Histological differentiation

     

0.003

 Well-moderate

45 (23.4)

4 (8.9)

12 (26.7)

14 (31.1)

15 (33.3)

 

 Poor

147 (76.6)

7 (4.8)

11 (7.5)

53 (36.1)

76 (51.7)

 

Laurén classification

     

0.127

 Intestinal

77 (40.1)

4 (5.2)

14 (18.2)

25 (32.5)

34 (44.2)

 

 Diffuse

73 (38)

7 (9.6)

5 (6.8)

24 (32.9)

37 (50.7)

 

 Mixed

42 (21.9)

0 (0)

4 (9.5)

18 (42.9)

20 (47.6)

 

LVI

     

<0.001

 Negative

94 (49)

11 (11.7)

19 (20.2)

39 (41.5)

25 (26.6)

 

 Positive

98 (51)

0 (0)

4 (4.1)

28 (28.6)

66 (67.3)

 

PNI

     

<0.001

 Negative

76 (39.6)

11 (14.5)

22 (28.9)

22 (28.9)

21 (27.6)

 

 Positive

116 (60.4)

0 (0)

1 (0.9)

45 (38.8)

70 (60.3)

 

AJCC ypT category

     

<0.001

 0

11 (5.7)

11 (100)

0 (0)

0 (0)

0 (0)

 

 1

20 (10.4)

0 (0)

12 (60)

5 (25)

3 (15)

 

 2

23 (12)

0 (0)

5 (21.7)

10 (43.5)

8 (34.8)

 

 3

57 (29.7)

0 (0)

5 (8.8)

29 (50.9)

23 (40.4)

 

 4

81 (42.2)

0 (0)

1 (1.2)

23 (28.4)

57 (70.4)

 

AJCC ypN category

     

<0.001

 0

55 (28.6)

9 (16.4)

13 (23.6)

19 (34.5)

14 (25.5)

 

 1

36 (18.8)

0 (0)

6 (16.7)

16 (44.4)

14 (38.9)

 

 2

50 (26)

0 (0)

3 (6)

21 (42)

26 (52)

 

 3

51 (26.6)

2 (3.9)

1 (2)

11 (21.6)

37 (72.5)

 

AJCC stage

     

<0.001

 0

9 (4.7)

9 (100)

0 (0)

0 (0)

0 (0)

 

 1

24 (12.5)

0 (0)

14 (58.3)

7 (29.2)

3 (12.5)

 

 2

53 (27.6)

2 (3.8)

6 (11.3)

21 (39.6)

24 (45.3)

 

 3

106 (55.2)

0 (0)

3 (2.8)

39 (36.8)

64 (60.4)

 

R0 resection

     

0.234

 Yes

159 (82.8)

11 (6.9)

20 (12.6)

57 (35.8)

71 (44.7)

 

 No

33 (17.2)

0 (0)

3 (9.1)

10 (30.3)

20 (60.6)

 

Adjuvant chemotherapy

     

0.912

 Not received

59 (30.7)

3 (5.1)

6 (10.2)

20 (33.9)

30 (50.8)

 

 Received

133 (69.3)

8 (6)

17 (35.3)

47 (35.3)

61 (45.9)

 
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