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Table 6 Relationships between clinicopathological characteristics and pathological response evaluated by Becker-TRG system

From: Comparison of five tumor regression grading systems for gastric adenocarcinoma after neoadjuvant chemotherapy: a retrospective study of 192 cases from National Cancer Center in China

Characteristics Total cases (n = 192), no. (%) Becker-TRG P value
1a (n = 11), no. (%) 1b (n = 23), no. (%) 2 (n = 67), no. (%) 3 (n = 91), no. (%)
Gender       0.142
 Male 139 (72.4) 10 (7.2) 20 (14.4) 45 (32.4) 64 (46)  
 Female 53 (27.6) 1 (1.9) 3 (5.7) 22 (41.5) 27 (50.9)  
Age       0.945
 < 55y 89 (46.4) 6 (6.7) 10 (11.2) 31 (34.8) 42 (47.2)  
 ≥ 55y 103 (53.6) 5 (4.9) 13 (12.6) 36 (35) 49 (47.6)  
Location       0.562
 Esophagogastric junction 44 (22.9) 1 (2.3) 4 (9.1) 15 (34.1) 24 (54.5)  
 Proximal gastric 71 (37) 7 (9.9) 8 (11.3) 24 (33.8) 32 (45.1)  
 Distal gastric 77 (40.1) 3 (3.9) 11 (14.3) 28 (36.4) 35 (45.5)  
Maximal diameter of tumor bed       0.003
 < 4.5 cm 108 (56.2) 9 (8.3) 20 (18.5) 35 (32.4) 44 (40.7)  
 4.5–8 cm 64 (33.3) 1 (1.6) 3 (4.7) 28 (43.8) 32 (50)  
 > 8 cm 20 (10.4) 1 (5) 0 (0) 4 (20) 15 (75)  
Histological differentiation       0.003
 Well-moderate 45 (23.4) 4 (8.9) 12 (26.7) 14 (31.1) 15 (33.3)  
 Poor 147 (76.6) 7 (4.8) 11 (7.5) 53 (36.1) 76 (51.7)  
Laurén classification       0.127
 Intestinal 77 (40.1) 4 (5.2) 14 (18.2) 25 (32.5) 34 (44.2)  
 Diffuse 73 (38) 7 (9.6) 5 (6.8) 24 (32.9) 37 (50.7)  
 Mixed 42 (21.9) 0 (0) 4 (9.5) 18 (42.9) 20 (47.6)  
LVI       <0.001
 Negative 94 (49) 11 (11.7) 19 (20.2) 39 (41.5) 25 (26.6)  
 Positive 98 (51) 0 (0) 4 (4.1) 28 (28.6) 66 (67.3)  
PNI       <0.001
 Negative 76 (39.6) 11 (14.5) 22 (28.9) 22 (28.9) 21 (27.6)  
 Positive 116 (60.4) 0 (0) 1 (0.9) 45 (38.8) 70 (60.3)  
AJCC ypT category       <0.001
 0 11 (5.7) 11 (100) 0 (0) 0 (0) 0 (0)  
 1 20 (10.4) 0 (0) 12 (60) 5 (25) 3 (15)  
 2 23 (12) 0 (0) 5 (21.7) 10 (43.5) 8 (34.8)  
 3 57 (29.7) 0 (0) 5 (8.8) 29 (50.9) 23 (40.4)  
 4 81 (42.2) 0 (0) 1 (1.2) 23 (28.4) 57 (70.4)  
AJCC ypN category       <0.001
 0 55 (28.6) 9 (16.4) 13 (23.6) 19 (34.5) 14 (25.5)  
 1 36 (18.8) 0 (0) 6 (16.7) 16 (44.4) 14 (38.9)  
 2 50 (26) 0 (0) 3 (6) 21 (42) 26 (52)  
 3 51 (26.6) 2 (3.9) 1 (2) 11 (21.6) 37 (72.5)  
AJCC stage       <0.001
 0 9 (4.7) 9 (100) 0 (0) 0 (0) 0 (0)  
 1 24 (12.5) 0 (0) 14 (58.3) 7 (29.2) 3 (12.5)  
 2 53 (27.6) 2 (3.8) 6 (11.3) 21 (39.6) 24 (45.3)  
 3 106 (55.2) 0 (0) 3 (2.8) 39 (36.8) 64 (60.4)  
R0 resection       0.234
 Yes 159 (82.8) 11 (6.9) 20 (12.6) 57 (35.8) 71 (44.7)  
 No 33 (17.2) 0 (0) 3 (9.1) 10 (30.3) 20 (60.6)  
Adjuvant chemotherapy       0.912
 Not received 59 (30.7) 3 (5.1) 6 (10.2) 20 (33.9) 30 (50.8)  
 Received 133 (69.3) 8 (6) 17 (35.3) 47 (35.3) 61 (45.9)