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Table 5 Relationships between clinicopathological characteristics and pathological response evaluated by China-TRG system

From: Comparison of five tumor regression grading systems for gastric adenocarcinoma after neoadjuvant chemotherapy: a retrospective study of 192 cases from National Cancer Center in China

Characteristics

Total cases (n = 192), no. (%)

China-TRG

P value

Severe response (n = 34), no. (%)

Moderate response (n = 57), no. (%)

Mild response (n = 101), no. (%)

Gender

    

0.063

 Male

139 (72.4)

30 (21.6)

41 (29.5)

68 (48.9)

 

 Female

53 (27.6)

4 (7.5)

16 (30.2)

33 (62.3)

 

Age

    

0.820

 < 55y

89 (46.4)

15 (16.9)

25 (28.1)

49 (55.1)

 

 ≥ 55y

103 (53.6)

19 (18.4)

32 (31.1)

52 (50.5)

 

Location

    

0.906

 Esophagogastric junction

44 (22.9)

6 (13.6)

14 (31.8)

24 (54.5)

 

 Proximal gastric

71 (37)

14 (19.7)

22 (31)

35 (49.3)

 

 Distal gastric

77 (40.1)

14 (18.2)

21 (27.3)

42 (54.5)

 

Maximal diameter of tumor bed

    

<0.001

 < 4.5 cm

108 (56.2)

28 (25.9)

32 (29.6)

48 (44.4)

 

 4.5–8 cm

64 (33.3)

5 (7.8)

21 (32.8)

38 (59.4)

 

 > 8 cm

20 (10.4)

1 (5)

4 (20)

15 (75)

 

Histological differentiation

    

0.001

 Well-moderate

45 (23.4)

16 (35.6)

12 (26.7)

17 (37.8)

 

 Poor

147 (76.6)

18 (12.2)

45 (30.6)

84 (57.1)

 

Laurén classification

    

0.264

 Intestinal

77 (40.1)

18 (23.4)

22 (28.6)

37 (48.1)

 

 Diffuse

73 (38)

13 (17.8)

20 (27.4)

40 (54.8)

 

 Mixed

42 (21.9)

3 (7.1)

15 (35.7)

24 (57.1)

 

LVI

    

<0.001

 Negative

94 (49)

30 (31.9)

35 (37.2)

29 (30.9)

 

 Positive

98 (51)

4 (4.1)

22 (22.4)

72 (73.5)

 

PNI

    

<0.001

 Negative

76 (39.6)

33 (43.4)

20 (26.3)

23 (30.3)

 

 Positive

116 (60.4)

1 (0.9)

37 (31.9)

78 (67.2)

 

AJCC ypT category

    

<0.001

 0

11 (5.7)

11 (100)

0 (0)

0 (0)

 

 1

20 (10.4)

12 (60)

5 (25)

3 (15)

 

 2

23 (12)

5 (21.7)

8 (34.8)

10 (43.5)

 

 3

57 (29.7)

5 (8.8)

26 (45.6)

26 (45.6)

 

 4

81 (42.2)

1 (1.2)

18 (22.2)

62 (76.5)

 

AJCC ypN category

    

<0.001

 0

55 (28.6)

22 (40)

18 (32.7)

15 (27.3)

 

 1

36 (18.8)

5 (13.9)

12 (33.3)

19 (52.8)

 

 2

50 (26)

4 (13.9)

19 (38)

27 (54)

 

 3

51 (26.6)

3 (5.9)

8 (15.7)

40 (78.4)

 

AJCC stage

    

<0.001

 0

9 (4.7)

9 (100)

0 (0)

0 (0)

 

 1

24 (12.5)

14 (58.3)

7 (29.2)

3 (12.5)

 

 2

53 (27.6)

7 (13.2)

17 (32.1)

29 (54.7)

 

 3

106 (55.2)

4 (3.8)

33 (31.1)

69 (65.1)

 

R0 resection

    

0.1

 Yes

159 (82.8)

31 (19.5)

49 (30.8)

79 (49.7)

 

 No

33 (17.2)

3 (9.1)

7 (21.2)

23 (69.7)

 

Adjuvant chemotherapy

    

0.975

 Not received

59 (30.7)

10 (16.9)

17 (28.8)

32 (54.2)

 

 Received

133 (69.3)

24 (18)

39 (29.3)

70 (52.6)

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