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Table 5 Relationships between clinicopathological characteristics and pathological response evaluated by China-TRG system

From: Comparison of five tumor regression grading systems for gastric adenocarcinoma after neoadjuvant chemotherapy: a retrospective study of 192 cases from National Cancer Center in China

Characteristics Total cases (n = 192), no. (%) China-TRG P value
Severe response (n = 34), no. (%) Moderate response (n = 57), no. (%) Mild response (n = 101), no. (%)
Gender      0.063
 Male 139 (72.4) 30 (21.6) 41 (29.5) 68 (48.9)  
 Female 53 (27.6) 4 (7.5) 16 (30.2) 33 (62.3)  
Age      0.820
 < 55y 89 (46.4) 15 (16.9) 25 (28.1) 49 (55.1)  
 ≥ 55y 103 (53.6) 19 (18.4) 32 (31.1) 52 (50.5)  
Location      0.906
 Esophagogastric junction 44 (22.9) 6 (13.6) 14 (31.8) 24 (54.5)  
 Proximal gastric 71 (37) 14 (19.7) 22 (31) 35 (49.3)  
 Distal gastric 77 (40.1) 14 (18.2) 21 (27.3) 42 (54.5)  
Maximal diameter of tumor bed      <0.001
 < 4.5 cm 108 (56.2) 28 (25.9) 32 (29.6) 48 (44.4)  
 4.5–8 cm 64 (33.3) 5 (7.8) 21 (32.8) 38 (59.4)  
 > 8 cm 20 (10.4) 1 (5) 4 (20) 15 (75)  
Histological differentiation      0.001
 Well-moderate 45 (23.4) 16 (35.6) 12 (26.7) 17 (37.8)  
 Poor 147 (76.6) 18 (12.2) 45 (30.6) 84 (57.1)  
Laurén classification      0.264
 Intestinal 77 (40.1) 18 (23.4) 22 (28.6) 37 (48.1)  
 Diffuse 73 (38) 13 (17.8) 20 (27.4) 40 (54.8)  
 Mixed 42 (21.9) 3 (7.1) 15 (35.7) 24 (57.1)  
LVI      <0.001
 Negative 94 (49) 30 (31.9) 35 (37.2) 29 (30.9)  
 Positive 98 (51) 4 (4.1) 22 (22.4) 72 (73.5)  
PNI      <0.001
 Negative 76 (39.6) 33 (43.4) 20 (26.3) 23 (30.3)  
 Positive 116 (60.4) 1 (0.9) 37 (31.9) 78 (67.2)  
AJCC ypT category      <0.001
 0 11 (5.7) 11 (100) 0 (0) 0 (0)  
 1 20 (10.4) 12 (60) 5 (25) 3 (15)  
 2 23 (12) 5 (21.7) 8 (34.8) 10 (43.5)  
 3 57 (29.7) 5 (8.8) 26 (45.6) 26 (45.6)  
 4 81 (42.2) 1 (1.2) 18 (22.2) 62 (76.5)  
AJCC ypN category      <0.001
 0 55 (28.6) 22 (40) 18 (32.7) 15 (27.3)  
 1 36 (18.8) 5 (13.9) 12 (33.3) 19 (52.8)  
 2 50 (26) 4 (13.9) 19 (38) 27 (54)  
 3 51 (26.6) 3 (5.9) 8 (15.7) 40 (78.4)  
AJCC stage      <0.001
 0 9 (4.7) 9 (100) 0 (0) 0 (0)  
 1 24 (12.5) 14 (58.3) 7 (29.2) 3 (12.5)  
 2 53 (27.6) 7 (13.2) 17 (32.1) 29 (54.7)  
 3 106 (55.2) 4 (3.8) 33 (31.1) 69 (65.1)  
R0 resection      0.1
 Yes 159 (82.8) 31 (19.5) 49 (30.8) 79 (49.7)  
 No 33 (17.2) 3 (9.1) 7 (21.2) 23 (69.7)  
Adjuvant chemotherapy      0.975
 Not received 59 (30.7) 10 (16.9) 17 (28.8) 32 (54.2)  
 Received 133 (69.3) 24 (18) 39 (29.3) 70 (52.6)