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Table 3 Frequency distribution of BSEP SNP rs2287622 alleles and genotypes in the research subjects on age stratification basis (n, %)

From: A preliminary investigation on single nucleotide polymorphism rs2287622 of bile salt export pump gene in patients with chronic hepatitis C virus infection in Hunan, China

Alleles or genotypes Overall 18- years old 40- years old
   Non-CHC CHC (n = 165) Non-CHC CHC (n = 58) Non-CHC CHC (n = 107)
   Health (n = 99) CHB (n = 99)   Health (n = 54) CHB (n = 41)   Health (n = 45) CHB (n = 58)  
Alleles C 147 (74.2) 144 (72.7) 245 (74.2) 85 (78.7) 62 (75.6) 81 (69.8) 62 (68.9) 82 (70.7) 164 (76.6)
  T 51 (25.8) 54 (27.3) 85 (25.8) 23 (21.3) 20 (24.4) 35 (30.2) 28 (31.1) 34 (29.3) 50 (23.4)
Genotypes CC 60 (60.6) 57 (57.6) 94 (57.0) 35 (64.8) 24 (58.5) 30 (51.7) 25 (55.6) 33 (56.9) 64 (59.8)
TT 12 (12.1) 12 (12.1) 14 (8.5) 4 (7.4) 3 (7.3) 7 (12.1) 8 (17.8) 9 (15.5) 7 (6.5)
TC 27 (27.3) 30 (30.3) 57 (34.5) 15 (27.8) 14 (34.1) 21 (36.2) 12 (26.7) 16 (27.6) 36 (33.6)
Alleles analysis Overall
 Chi-square 0.172 2.391 2.517
P value 0.918 0.302 0.284
CHC vs Non-CHC
 Chi-square 0.053 2.156 2.433
P value 0.817 0.142 0.119
Risk of CHC OR (95%CI) (C vs T) 1.040 (0.746–1.450) 0.677 (0.402–1.141) 1.412 (0.914–2.181)
Genotypes analysis Overall
 Chi-square 2.379 2.340a 5.516
P value 0.666 0.674 0.238
CHC vs Non-CHC
 Chi-square 2.157 1.892 5.388
P value 0.340 0.388 0.068
Risk of CHC
 CC vs TT
  Chi-square 0.779 1.395 4.355
   P value 0.377 0.238 0.037
  OR (95%CI) 1.377 (0.675–2.809) 0.508 (0.163–1.584) 2.680 (1.037–6.924)
 CC + TC vs TT
  Chi-square 1.270 0.957 5.146
   P value 0.260 0.328 0.023
  OR (95%CI) 1.488 (0.743–2.979) 0.580 (0.192–1.746) 2.824 (1.118–7.130)
 TT + TC vs CC
  Chi-square 0.166 1.595 0.264
   P value 0.683 0.207 0.607
  OR (95%CI) 1.091 (0.718–1.658) 1.530 (0.790–2.963) 0.866 (0.500–1.499)
 TC vs TT
  Chi-square 1.982 0.284 5.124
   P value 0.159 0.594 0.024
  OR (95%CI) 1.714 (0.806–3.645) 0.724 (0.221–2.377) 3.122 (1.138–8.567)
  1. CHC patients with chronic HCV infection, CHB patients with chronic HBV infection, Healthy Healthy individuals, OR odds ratio, CI confidence interval
  2. aContinuity Corrected Chi-square