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Table 3 Frequency distribution of BSEP SNP rs2287622 alleles and genotypes in the research subjects on age stratification basis (n, %)

From: A preliminary investigation on single nucleotide polymorphism rs2287622 of bile salt export pump gene in patients with chronic hepatitis C virus infection in Hunan, China

Alleles or genotypes

Overall

18- years old

40- years old

  

Non-CHC

CHC (n = 165)

Non-CHC

CHC (n = 58)

Non-CHC

CHC (n = 107)

  

Health (n = 99)

CHB (n = 99)

 

Health (n = 54)

CHB (n = 41)

 

Health (n = 45)

CHB (n = 58)

 

Alleles

C

147 (74.2)

144 (72.7)

245 (74.2)

85 (78.7)

62 (75.6)

81 (69.8)

62 (68.9)

82 (70.7)

164 (76.6)

 

T

51 (25.8)

54 (27.3)

85 (25.8)

23 (21.3)

20 (24.4)

35 (30.2)

28 (31.1)

34 (29.3)

50 (23.4)

Genotypes

CC

60 (60.6)

57 (57.6)

94 (57.0)

35 (64.8)

24 (58.5)

30 (51.7)

25 (55.6)

33 (56.9)

64 (59.8)

TT

12 (12.1)

12 (12.1)

14 (8.5)

4 (7.4)

3 (7.3)

7 (12.1)

8 (17.8)

9 (15.5)

7 (6.5)

TC

27 (27.3)

30 (30.3)

57 (34.5)

15 (27.8)

14 (34.1)

21 (36.2)

12 (26.7)

16 (27.6)

36 (33.6)

Alleles analysis

Overall

 Chi-square

0.172

2.391

2.517

P value

0.918

0.302

0.284

CHC vs Non-CHC

 Chi-square

0.053

2.156

2.433

P value

0.817

0.142

0.119

Risk of CHC OR (95%CI) (C vs T)

1.040 (0.746–1.450)

0.677 (0.402–1.141)

1.412 (0.914–2.181)

Genotypes analysis

Overall

 Chi-square

2.379

2.340a

5.516

P value

0.666

0.674

0.238

CHC vs Non-CHC

 Chi-square

2.157

1.892

5.388

P value

0.340

0.388

0.068

Risk of CHC

 CC vs TT

  Chi-square

0.779

1.395

4.355

   P value

0.377

0.238

0.037

  OR (95%CI)

1.377 (0.675–2.809)

0.508 (0.163–1.584)

2.680 (1.037–6.924)

 CC + TC vs TT

  Chi-square

1.270

0.957

5.146

   P value

0.260

0.328

0.023

  OR (95%CI)

1.488 (0.743–2.979)

0.580 (0.192–1.746)

2.824 (1.118–7.130)

 TT + TC vs CC

  Chi-square

0.166

1.595

0.264

   P value

0.683

0.207

0.607

  OR (95%CI)

1.091 (0.718–1.658)

1.530 (0.790–2.963)

0.866 (0.500–1.499)

 TC vs TT

  Chi-square

1.982

0.284

5.124

   P value

0.159

0.594

0.024

  OR (95%CI)

1.714 (0.806–3.645)

0.724 (0.221–2.377)

3.122 (1.138–8.567)

  1. CHC patients with chronic HCV infection, CHB patients with chronic HBV infection, Healthy Healthy individuals, OR odds ratio, CI confidence interval
  2. aContinuity Corrected Chi-square