Fig. 1

Study design. ^aRibavirin given twice daily at a dose of 1000–1200 mg. Follow-up therapy with pegIFN/RBV was based on on-treatment response and was initiated only if: Week 4 HCV RNA ≥25 IU/mL (Panels 1–3: 36 weeks of follow-up therapy); Week 4 HCV RNA <25 IU/mL detectable or HCV RNA confirmed detectable between Week 4 and Week 11 (Panels 1–2: 12 weeks of follow-up therapy). GT genotype, HCV hepatitis C virus, pegIFN pegylated interferon α-2a, RBV ribavirin, RTV ritonavir, SMV simeprevir, SVR12 sustained virologic response 12 weeks after end of treatment