First clinical experience in 14 patients treated with ADVOS: a study on feasibility, safety and efficacy of a new type of albumin dialysis

Table 2 Patients’ baseline characteristics

Patient	Study	Type of Liver failure (LF)	Aetiology	Precipitating event	Age [years]	Gender	CANONIC [ACLF-grade]	Child-Pugh [points]	MELD [points]	CLIF-SOFA [points]	Acute renal failure
P1	Post-CE	acute-on-chronic LF	alcoholic	SBP	59	female	3	12 (C)	40	12	+
P2	Post-CE	acute-on-chronic LF	alcoholic	ASH	52	female	2	12 (C)	26	14	+
P3	Post-CE	acute-on-chronic LF	alcoholic	ASH	53	male	3	13 (C)	37	15	+
P4	Post-CE	acute-on-chronic LF	alcoholic	Infection	61	male	3	11 (C)	35	15	+
P5	Post-CE	acute-on-chronic LF	alcoholic	Ischemia	68	female	3	12 (C)	24	18	+
P6	Post-CE	acute-on-chronic LF	alcoholic	ASH, sepsis	48	female	3	12 (C)	44	13	+
P7	HEPATICUS-1	acute-on-chronic LF	alcoholic	GI-bleeding	54	male	3	14 (C)	29	14	+
P8	HEPATICUS-1	acute-on-chronic LF	alcoholic	GI-bleeding	38	male	3	13 (C)	32	17	+
P9	HEPATICUS-1	acute-on-chronic LF	alcoholic	ASH	28	male	3	11 (C)	34	13	+
P10	HEPATICUS-2	“Secondary” LF	Sepsis	n.a.	66	female	n.a.	n.a.	19	18	+
P11	HEPATICUS-2	“Secondary” LF	ASH	n.a.	39	male	n.a.	n.a.	39	9	+
P12	HEPATICUS-2	“Secondary” LF	Drug-induced	n.a.	73	male	n.a.	n.a.	38	15	+
P13	HEPATICUS-2	“Secondary” LF	ASH	n.a.	56	female	n.a.	n.a.	35	14	+
P14	Post-CE	“Secondary” LF	Sepsis	n.a.	67	male	n.a.	n.a.	40	18	+
Mean ± SD or number [%]					54 ± 13	8 male; 6 female	2.9 ± 0.3	12 ± 1	34 ± 7	15 ± 3	100%

ASH alcoholic steatohepatitis, SBP spontaneous bacterial peritonitis, MELD model of end-stage liver disease
CLIF-SOFA chronic liver-failure sequential organ failure assessment, CANONIC CLIF acute-on-chronic liver failure in cirrhosis
n.a not applicable