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Fig. 6 | BMC Gastroenterology

Fig. 6

From: Relevance of FXR-p62/SQSTM1 pathway for survival and protection of mouse hepatocytes and liver, especially with steatosis

Fig. 6

Schematic illustration of a crucial role of FXR-p62/SQSTM1 pathway in liver/hepatocyte protection. FXR upregulates Nrf2-regulated antioxidants, activates (phosphorylates) pro-survival Akt and suppresses harmful FasL/Fas via p62/SQSTM1, and therefore protects against liver/hepatocyte injury. FXR also improves steatosis of hepatocytes/liver possibly by suppressing LXR/SREBP-1c/FAS adipogenic pathway via SHP. FXR may be one of the key molecules in protecting steatotic hepatocyte/liver injury

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