Skip to main content
Fig. 3 | BMC Gastroenterology

Fig. 3

From: Relevance of FXR-p62/SQSTM1 pathway for survival and protection of mouse hepatocytes and liver, especially with steatosis

Fig. 3

FXR-agonist improved cell survival through p62/SQSTM1 in AML12 liver cells. a GW4064 improved cell survival significantly at 0.5, 1.0 and 5.0 μM, showing the peak effect at 1.0 μM. (*: p < 0.05 vs non-stimulant group) GW4064 significantly suppressed LDH release 72 h after the treatment at 0.5, 1.0 and 5.0 μM. (**: p < 0.05 vs GW-0 μM group) b Cell survival effects of GW4064 was cancelled partially but significantly by p62/SQSTM1 knockdown (10nM of siRNA of p62/SQSTM1 gene). (* : p < 0.05 vs no siRNA group; **: p < 0.05 vs no siRNA & GAPDH siRNA groups) Each experimental group consisted of at least three independent experiments. Data are expressed as mean ± SEM. p values <0.05 were considered statistically significant

Back to article page