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Table 4 UGT1A11 polymorphisms and their relationships with clinical characteristics

From: Clinical significance of UGT1A1 polymorphism and expression of ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A in gastric cancer

Clinical features

*28

−3156 GA

211GA

TA 6/6

TA 6/7

TA 7/7

GG

GA

AA

GG

GA

AA

Gender

 Male

64 (84.2)

10 (13.2)

2 (2.6)

64 (84.2)

10 (13.2)

2 (2.6)

49 (64.5)

23 (30.3)

4 (5.3)

 Female

17 (77.3)

5 (22.7)

0 (0.0)

17 (77.3)

5 (22.7)

0 (0.0)

13 (59.1)

9 (40.9)

0 (0.0)

χ 2, P

2.046, 0.359

2.046, 0.359

2.674, 0.263

Age

  < 57 years

33 (80.5)

8 (19.5)

0 (0.0)

33 (80.5)

8 (19.5)

0 (0.0)

26 (63.4)

14 (34.1)

1 (2.4)

  > 57 years

48 (84.2)

7 (12.3)

2 (3.5)

48 (84.2)

7 (12.3)

2 (3.5)

36 (63.2)

18 (31.6)

3 (5.3)

χ 2, P

3.009, 0.222

3.009, 0.222

0.544, 0.762

Family history

 Yes

4 (80.0)

1 (20.0)

0 (0.0)

4 (80.0)

1 (20.0)

0 (0.0)

2 (40.0)

2 (40.0)

1 (20.0)

 No

77 (82.8)

14 (15.1)

2 (2.2)

77 (82.8)

14 (15.1)

2 (2.2)

60 (64.5)

30 (62.3)

3 (3.2)

χ 2, P

0.283, 0.868

0.283, 0.868

2.364, 0.307

Alcohol history

 Yes

29 (90.6)

3 (9.4)

0 (0.0)

29 (90.6)

3 (9.4)

0 (0.0)

21 (65.6)

9 (28.1)

2 (6.3)

 No

52 (78.8)

12 (18.2)

2 (3.0)

52 (78.8)

12 (18.2)

2 (3.0)

41 (62.1)

23 (34.8)

2 (3.0)

χ 2, P

3.132, 0.209

3.132, 0.209

0.861, 0.650

Histological type

 Tubular adenocarcinoma

60 (80.0)

13 (17.3)

2 (2.7)

60 (80.0)

13 (17.3)

2 (2.7)

54 (72.0)

19 (25.3)

2 (2.7)

 Non-tubular adenocarcinoma

21 (91.3)

2 (8.7)

0 (0.0)

21 (91.3)

2 (8.7)

0 (0.0)

8 (34.8)

13 (56.5)

2 (8.7)

χ 2, P

2.308, 0.315

2.308, 0.315

10.339, 0.006

Differentiation

 Undifferentiated

13 (86.7)

2 (13.3)

0 (0.0)

13 (86.7)

2 (13.3)

0 (0.0)

6 (40.0)

7 (46.7)

2 (13.3)

 Poor

51 (85.0)

8 (13.3)

1 (1.7)

51 (85.0)

8 (13.3)

1 (1.7)

41 (68.3)

18 (30.0)

1 (1.7)

 Moderate

17 (77.3)

4 (18.2)

1 (4.5)

17 (77.3)

4 (18.2)

1 (4.5)

14 (63.6)

7 (31.8)

1 (4.5)

 Well

0 (0.0)

1 (100.0)

0 (0.0)

0 (0.0)

1 (100.0)

0 (0.0)

1 (100.0)

0 (0.0)

0 (0.0)

χ 2, P

5.368, 0.498

5.368, 0.498

6.642, 0.355

Growth patterns

 Expansive

2 (100.0)

0 (0.0)

0 (0.0)

2 (100.0)

0 (0.0)

0 (0.0)

1 (50.0)

1 (50.0)

0 (0.0)

 Invasive

56 (78.9)

13 (18.3)

2 (2.8)

56 (78.9)

13 (18.3)

2 (2.8)

47 (66.2)

21 (29.6)

3 (4.2)

 Expansive + invasive

23 (92.0)

2 (8.0)

0 (0.0)

23 (92.0)

2 (8.0)

0 (0.0)

14 (56.0)

10 (40.0)

1 (4.0)

χ 2, P

3.800, 0.434

3.800, 0.434

1.295, 0.862

χ 2, P

1.239, 0.538

1.239, 0.538

2.959, 0.228

Depth of invasion

 T1

11 (78.6)

1 (7.1)

2 (14.2)

11 (78.6)

1 (7.1)

2 (14.2)

11 (78.6)

3 (21.4)

0 (0.0)

 T2

2 (40.0)

3 (60.0)

0 (0.0)

2 (40.0)

3 (60.0)

0 (0.0)

4 (80.0)

1 (20.0)

0 (0.0)

 T3

2 (66.7)

1 (33.3)

0 (0.0)

2 (66.7)

1 (33.3)

0 (0.0)

3 (100.0)

0 (0.0)

0 (0.0)

 T4

66 (86.8)

10 (13.2)

0 (0.0)

66 (86.8)

10 (13.2)

0 (0.0)

44 (57.9)

28 (36.8)

4 (5.3)

χ 2, P

14.637, 0.023

14.637, 0.023

6.870, 0.333

Lymph node metastasis

 N0

41 (78.8)

10 (19.2)

1 (1.9)

41 (78.8)

10 (19.2)

1 (1.9)

35 (67.3)

16 (30.8)

1 (1.9)

 N1

26 (81.3)

5 (15.6)

1 (3.1)

26 (81.3)

5 (15.6)

1 (3.1)

21 (65.6)

9 (28.1)

2 (6.3)

 N2

11 (100)

0 (0.0)

0 (0.0)

11 (100)

0 (0.0)

0 (0.0)

3 (27.3)

7 (63.6)

1 (9.1)

Undetermined

3 (100.0)

0 (0.0)

0 (0.0)

3 (100.0)

0 (0.0)

0 (0.0)

3 (100.0)

0 (0.0)

0 (0.0)

χ 2, P

6.082, 0.414

6.082, 0.414

10.126, 0.119

Distant metastasis

 M0

69 (80.2)

15 (17.4)

2 (2.3)

69 (80.2)

15 (17.4)

2 (2.3)

57 (66.3)

25 (29.1)

4 (4.7)

 M1

12 (100)

0 (0.0)

0 (0.0)

12 (100)

0 (0.0)

0 (0.0)

5 (41.7)

7 (58.3)

0 (0.0)

χ 2, P

4.912, 0.086

4.912, 0.086

4.485, 0.106

TNM staging

 I

13 (72.2)

3 (16.7)

2 (11.1)

13 (72.2)

3 (16.7)

2 (11.1)

14 (77.8)

4 (22.2)

0 (0.0)

 IIA-IIC

23 (79.3)

6 (20.7)

0 (0.0)

23 (79.3)

6 (20.7)

0 (0.0)

22 (75.9)

6 (20.7)

1 (3.4)

 IIIA-IIIC

33 (84.6)

6 (15.4)

0 (0.0)

33 (84.6)

6 (15.4)

0 (0.0)

21 (53.8)

15 (38.5)

3 (7.7)

 IVA-IVB

12 (100)

0 (0.0)

0 (0.0)

12 (100)

0 (0.0)

0 (0.0)

5 (41.7)

7 (58.3)

0 (0.0)

χ 2, P

11.682, 0.069

11.682, 0.069

10.771, 0.096

  1. The values in bold indicate the statistically significant difference