Table 2 Relationships between gene expression and clinical characteristics
Clinical features | ERCC1 | BRCA1 | TYMS | RRM1 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Low | Middle | High | Low | Middle | High | Low | Middle | High | Low | Middle | High | |
Gender | ||||||||||||
 Male | 11 (14.5) | 46 (60.5) | 19 (25.0) | 6 (7.9) | 39 (51.3) | 31 (40.8) | 24 (31.6) | 36 (47.4) | 16 (21.1) | 45 (31.6) | 25 (31.6) | 6 (31.6) |
 Female | 6 (27.3) | 8 (36.4) | 8 (36.4) | 3 (13.6) | 11 (50.0) | 8 (36.4) | 6 (27.3) | 9 (40.9) | 7 (31.8) | 7 (31.6) | 11 (31.6) | 4 (31.6) |
χ 2, P | 4.219, .219 | 0.702, 0.704 | 1.101, 0.577 | 5.541, 0.063 | ||||||||
Age | ||||||||||||
  < 57 years | 7 (17.1) | 19 (46.3) | 15 (36.6) | 6 (14.6) | 22 (53.7) | 13 (31.7) | 18 (43.9) | 14 (34.1) | 9 (22.0) | 20 (48.8) | 19 (46.3) | 2 (4.9) |
  > 57 years | 10 (17.5) | 35 (61.4) | 12 (21.1) | 3 (5.3) | 28 (49.1) | 26 (45.6) | 12 (21.1) | 31 (54.4) | 14 (24.6) | 32 (56.1) | 17 (29.8) | 8 (14.0) |
χ 2, P | 3.073, 0.215 | 3.535, 0.171 | 6.264, 0.044 | 3.974, 0.137 | ||||||||
Family history | ||||||||||||
 Yes | 0 (0.0) | 3 (60.0) | 2 (40.0) | 1 (20.0) | 3 (60.0) | 1 (20.0) | 2 (40.0) | 2 (40.0) | 1 (20.0) | 2 (40.0) | 3 (60.0) | 0 (0.0) |
 No | 17 (18.3) | 51 (54.8) | 25 (26.9) | 8 (8.6) | 47 (50.5) | 38 (40.9) | 28 (30.1) | 43 (46.2) | 22 (23.7) | 50 (53.8) | 33 (35.5) | 10 (10.8) |
χ 2, P | 2.065, 0.356 | 1.219, 0.544 | 0.209, 0.901 | 1.889, 0.389 | ||||||||
Alcohol history | ||||||||||||
 Yes | 6 (18.8) | 18 (56.3) | 8 (25.0) | 2 (6.3) | 15 (46.9) | 15 (46.9) | 7 (21.9) | 17 (53.1) | 8 (25.0) | 15 (46.9) | 14 (43.8) | 3 (9.4) |
 No | 11 (16.7) | 36 (54.5) | 19 (28.8) | 7 (10.6) | 35 (53.0) | 24 (36.4) | 23 (34.8) | 28 (42.4) | 15 (22.7) | 37 (56.1) | 22 (33.3) | 7 (10.6) |
χ 2, P | 0.178, 0.915 | 1.204, 0.548 | 1.770, 0.413 | 1.011, 0.603 | ||||||||
Histological type | ||||||||||||
 Tubular adenocarcinoma | 14 (18.7) | 40 (53.3) | 21 (28.0) | 6 (8.0) | 37 (49.3) | 32 (42.7) | 20 (26.7) | 36 (48.0) | 19 (25.3) | 40 (53.3) | 26 (34.7) | 9 (12.0) |
 Non-tubular adenocarcinoma | 3 (13.0) | 14 (60.9) | 6 (26.1) | 3 (13.0) | 13 (56.5) | 7 (30.4) | 10 (43.5) | 9 (39.1) | 4 (17.4) | 12 (52.2) | 10 (43.5) | 1 (4.3) |
χ 2, P | 0.526, 0.769 | 1.328, 0.515 | 2.400, 0.301 | 1.387, 0.500 | ||||||||
Differentiation | ||||||||||||
 Undifferentiated | 2 (13.3) | 8 (53.3) | 5 (33.3) | 2 (13.3) | 8 (53.3) | 5 (33.3) | 7 (46.7) | 5 (33.3) | 3 (20.0) | 7 (46.7) | 8 (53.3) | 0 (0.0) |
  Poor | 10 (16.7) | 33 (55.0) | 17 (28.3) | 4 (6.7) | 32 (53.3) | 24 (40.0) | 15 (25.0) | 31 (51.7) | 14 (23.3) | 31 (51.7) | 23 (38.3) | 6 (10.0) |
  Moderate | 4 (18.2) | 13 (59.1) | 5 (22.7) | 3 (13.6) | 10 (45.5) | 9 (40.9) | 8 (36.4) | 9 (40.9) | 5 (22.7) | 14 (63.6) | 5 (22.7) | 3 (13.6) |
  Well | 1 (100.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (100.0) | 0 (0.0) | 0 (0.0) | 1 (100.0) | 0 (0.0) | 0 (0.0) | 1 (100.0) |
χ 2, P | 4.132, 0.659 | 3.350, 0.764 | 6.067, 0.416 | 10.825, 0.094 | ||||||||
Growth patterns | ||||||||||||
Expansive | 0 (0.0) | 0 (0.0) | 2 (100.0) | 0 (0.0) | 0 (0.0) | 2 (100.0) | 2 (100.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 0 (0.0) |
 Invasive | 11 (15.5) | 41 (57.7) | 19 (26.8) | 7 (9.9) | 34 (47.9) | 30 (42.3) | 18 (25.4) | 33 (46.5) | 20 (28.2) | 34 (47.9) | 30 (42.3) | 7 (9.9) |
 Expansive + invasive | 6 (24.0) | 13 (52.0) | 6 (24.0) | 2 (8.0) | 16 (64.0) | 7 (28.0) | 10 (40.0) | 12 (48.0) | 3 (12.0) | 17 (68.0) | 5 (20.0) | 3 (12.0) |
χ 2, P | 6.141 | 0.189 |  | 5.744 | 0.219 |  | 8.438 | 0.077 |  | 4.765 | 0.312 |  |
Depth of invasion | ||||||||||||
 T1 | 2 (14.3) | 5 (35.7) | 7 (50.0) | 1 (7.1) | 8 (57.1) | 5 (35.7) | 7 (50.0) | 4 (28.6) | 3 (21.4) | 9 (64.3) | 4 (28.6) | 1 (7.1) |
 T2 | 2 (40.0) | 2 (40.0) | 1 (20.0) | 0 (0.0) | 2 (40.0) | 3 (60.0) | 2 (40.0) | 2 (40.0) | 1 (20.0) | 2 (40.0) | 2 (40.0) | 1 (20.0) |
 T3 | 1 (33.3) | 2 (66.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (100.0) | 0 (0.0) | 1 (33.3) | 2 (66.6) | 2 (66.6) | 0 (0.0) | 1 (33.3) |
 T4 | 12 (15.8) | 45 (59.2) | 19 (25.0) | 8 (10.5) | 40 (52.6) | 28 (36.8) | 21 (27.6) | 38 (50.0) | 17 (22.4) | 39 (51.3) | 30 (39.5) | 7 (9.2) |
χ 2, P | 7.241 | 0.299 |  | 7.599 | 0.269 |  | 6.797 | 0.340 |  | 4.839 | 0.621 |  |
Lymph node metastasis | ||||||||||||
 N0 | 10 (19.2) | 28 (53.8) | 14 (26.9) | 3 (5.8) | 30 (57.7) | 19 (36.5) | 18 (34.6) | 22 (42.3) | 12 (23.1) | 29 (55.8) | 19 (36.5) | 4 (7.7) |
 N1 | 5 (15.6) | 18 (56.3) | 9 (28.1) | 3 (9.4) | 14 (43.8) | 15 (46.9) | 8 (25.0) | 15 (46.9) | 9 (28.1) | 14 (43.8) | 15 (46.9) | 3 (9.4) |
 N2 | 1 (9.1) | 7 (63.6) | 3 (27.3) | 2 (18.2) | 6 (54.5) | 3 (27.3) | 3 (27.3) | 7 (63.6) | 1 (9.1) | 6 (54.5) | 2 (18.2) | 3 (27.3) |
 Undetermined | 1 (33.3) | 1 (33.3) | 1 (33.3) | 1 (33.3) | 0 (0.0) | 2 (66.7) | 1 (33.3) | 1 (33.3) | 1 (33.3) | 3 (100.0) | 0 (0.0) | 0 (0.0) |
χ 2, P | 1.538 | 0.957 |  | 7.979 | 0.240 |  | 3.262 | 0.775 |  | 9.043 | 0.172 |  |
Distant metastasis | ||||||||||||
 M0 | 15 (17.4) | 48 (55.8) | 23 (26.7) | 7 (8.1) | 45 (52.3) | 34 (39.5) | 28 (32.6) | 38 (44.2) | 20 (23.3) | 44 (51.2) | 33 (38.4) | 9 (10.5) |
 M1 | 2 (16.7) | 6 (50.0) | 4 (33.3) | 2 (16.7) | 5 (41.7) | 5 (41.7) | 2 (16.7) | 7 (58.3) | 3 (25.0) | 8 (66.7) | 3 (25.0) | 1 (8.3) |
χ 2, P | 0.227, 0.893 | 0.954, 0.621 | 1.460, 0.482 | 1.065, 0.587 | ||||||||
TNM staging | ||||||||||||
 I | 4 (22.2) | 6 (33.3) | 8 (44.4) | 1 (5.6) | 10 (55.6) | 7 (38.9) | 9 (50.0) | 5 (27.8) | 4 (22.2) | 11 (61.1) | 5 (27.8) | 2 (11.1) |
 IIA-IIC | 5 (17.2) | 19 (65.5) | 5 (17.2) | 2 (6.9) | 16 (55.2) | 11 (37.9) | 7 (24.1) | 15 (51.7) | 7 (24.1) | 16 (55.2) | 11 (37.9) | 2 (6.9) |
 IIIA-IIIC | 6 (15.4) | 23 (59.0) | 10 (25.6) | 4 (10.3) | 19 (48.7) | 16 (41.0) | 12 (30.8) | 18 (46.2) | 9 (23.1) | 17 (43.6) | 17 (43.6) | 5 (12.8) |
 IVA-IVB | 2 (16.7) | 6 (50.0) | 4 (33.3) | 2 (16.7) | 5 (41.7) | 5 (41.7) | 2 (16.7) | 7 (58.3) | 3 (25.0) | 8 (66.7) | 3 (25.0) | 3 (8.3) |
χ 2, P | 5.876, 0.437 | 1.598, 0.953 | 5.308, 0.505 | 3.393, 0.758 | ||||||||