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Table 4 Correlation between changes in levels of clinical parameters and histological scores

From: Analysis of association between circulating miR-122 and histopathological features of nonalcoholic fatty liver disease in patients free of hepatocellular carcinoma

 

ΔSteatosis

ΔBallooning

ΔLobular inflammation

ΔStage

r

P

r

P

r

P

r

P

ΔAge

0.4

0.011

0.3

0.049

0.3

0.055

0.4

0.026

ΔBody mass index

0.3

0.045

0.3

0.045

0.6

<0.001

0.5

0.004

ΔSerum aspartate aminotransferase

0.4

0.018

0.3

0.126

0.6

<0.001

0.6

<0.001

ΔSerum alanine aminotransferase

0.4

0.018

0.3

0.108

0.5

0.001

0.3

0.054

ΔGamma-glutamyl transpeptidase

0.1

0.555

0.3

0.099

0.3

0.043

0.3

0.044

ΔSerum albumin

-0.1

0.748

-0.1

0.393

-0.3

0.110

-0.2

0.165

ΔPlatelet count

0.1

0.740

0.0

0.918

-0.2

0.145

-0.1

0.416

ΔFasting plasma glucose

0.0

0.913

0.2

0.390

0.3

0.102

0.3

0.100

ΔUric acid

-0.1

0.671

0.1

0.539

0.2

0.374

0.3

0.089

ΔTotal cholesterol

0.1

0.636

0.3

0.096

0.0

0.992

0.1

0.546

ΔTriglycerides

0.2

0.213

0.1

0.530

0.2

0.195

0.4

0.031

ΔHigh-density lipoprotein cholesterol

0.1

0.738

0.1

0.670

-0.3

0.056

-0.2

0.218

ΔLow-density lipoprotein cholesterol

0.0

0.942

0.2

0.248

0.0

0.855

0.0

0.849

ΔNon high-density lipoprotein cholesterol

0.1

0.675

0.3

0.109

0.1

0.597

0.1

0.385

ΔFerritin

0.3

0.048

0.3

0.063

0.6

<0.001

0.4

0.007

ΔHyaluronic acid

0.2

0.366

0.4

0.036

0.3

0.075

0.5

0.002

Serum miR-122 ratioa

0.5

0.001

0.2

0.226

0.6

<0.001

0.5

0.002

  1. aSerum miR-122 ratio represented the ratio of serum miR-122 level at second biopsy to that at first biopsy
  2. Changes (Δ) in levels of clinical parameters and histopathological scores were calculated by: value at second biopsy minus value at first biopsy