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Table 1 Clinical characteristics at the time of the first and second liver biopsies, of 36 patients with NAFLD free of hepatocellular carcinoma

From: Analysis of association between circulating miR-122 and histopathological features of nonalcoholic fatty liver disease in patients free of hepatocellular carcinoma

  First biopsy Second biopsy
Demographic data
 Number of patients 36 36
 Gender (Male/Female) 20/16 20/16
Histological findings
 Steatosis (0/1/2/3) 0/8/20/8 1/15/15/5
 Lobular inflammation (0/1/2/3) 4/14/13/5 2/20/14/0
 Ballooning (0/1/2) 2/21/13 4/23/9
 Stage (0/1/2/3/4) 5/13/6/11/1 2/16/5/12/1
 Matteoni classification (type 1/2/3/4) 1/1/3/31 0/1/1/33
 NAFLD activity score (≤2/3, 4/≥5) 2/12/22 4/16/16
Clinical parameters
 Age (years) 49 (24-69) 59 (26-70)
 Body mass index (kg/m2) 25.6 (20.5-36.5) 25.5 (19.1-33.6)
 Serum aspartate aminotransferase (IU/l) 61 (19-152) 37 (14-132)
 Serum alanine aminotransferase (IU/l) 104 (28-303) 49 (8-304)
 Gamma-glutamyl transpeptidase (IU/l) 65 (17-505) 43 (9-359)
 Serum albumin (g/dl) 4.1 (3.4-4.9) 4.0 (2.8-4.5)
 Platelet count (×103/mm3) 210 (117-389) 207 (111-296)
 Fasting plasma glucose (mg/dl) 94 (65-142) 106 (73-278)
 Uric acid (mg/dl) 6.0 (1.8-9.5) 5.9 (1.5-9.2)
 Total cholesterol (mg/dl) 209 (130-290) 202 (131-270)
 Triglycerides (mg/dl) 137 (62-254) 131 (54-295)
 High-density lipoprotein cholesterol (mg/dl) 44 (29-85) 45 (27-73)
 Low-density lipoprotein cholesterol (mg/dl) 129 (66-205) 123 (64-175)
 Non high-density lipoprotein cholesterol (mg/dl) 162 (95-228) 150 (95-219)
 Serum ferritin (μg/l) 265 (<10-1,472) 202 (13-1,018)
 Hyaluronic acid (μg/l) 34 (8-561) 30 (0-222)
 Serum miR-122 (fold change) 1.03 (0.13-7.63) 0.66 (0.03-7.65)
  1. Data are number of patients or median (range) values