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Table 6 Independent factors associate with mortality in drug-induced liver injury (DILI)

From: The incidence, presentation, outcomes, risk of mortality and economic data of drug-induced liver injury from a national database in Thailand: a population-base study

  Univariate Cox regression Multiple Cox regression
  Crude Hazard Ratio 95 % CI p Adjusted Hazard Ratio 95 % CI p
Acetaminophen 0.13 0.07–0.22 <0.001 0.24 0.13–0.42 <0.001
Cirrhosis 2.60 2.24–3.02 <0.001 2.72 2.33–3.19 <0.001
Age ≥ 60 years 1.74 1.61–1.89 <0.001 2.16 1.96–2.38 <0.001
HIV 1.39 1.26–1.53 <0.001 2.11 1.88–2.36 <0.001
Chronic kidney diseases 1.94 1.63–2.32 <0.001 1.59 1.33–1.90 <0.001
COPD/bronchiectasis 1.92 1.46–2.53 <0.001 1.55 1.17–2.04 0.002
Malnutrition 1.87 1.44–2.42 <0.001 1.43 1.10–1.86 0.007
Male 1.41 1.29–1.53 <0.001 1.31 1.21–1.43 <0.001
Ascites 2.17 1.56–3.02 <0.001 1.40 0.97–1.98 0.052
Mushroom 0.14 0.00–1.03 0.053 0.22 0.03–1.53 0.125
  1. HIV human immunodeficiency virus, COPD chronic obstructive pulmonary disease, CI confidence interval