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Table 3 Characteristics of proteins with enhanced expression level in the fecal microbiota from LC patients or specific for patients’ intestinal microbiota compared with the normal

From: Cirrhosis related functionality characteristic of the fecal microbiota as revealed by a metaproteomic approach

No. Description Gene name Length MW [Da] KO COG Subcellular location Signal peptide prediction GO Functonal Categorya
Proteins with enhanced expression level in the fecal microbiota from LC patients
 1 Chaperone protein DnaK dnaK 620 66,266 k04043 COG0443 Cytoplasmic Absence GO:0006457 GO:0000166 GO:0005524 GO:0051082 O
 2 Glutamate dehydrogenase proS 604 66,842 k01881 COG0442 Cytoplasmic Absence GO:0006520 GO:0055114 GO:0016491 GO:0016639 J
 3 Elongation factor G fusA 709 78,383 k02355 COG0480 Cytoplasmic Absence GO:0006412 GO:0006414 GO:0000166 GO:0003746 GO:0003924 GO:0005525 GO:0005622 GO:0005737 J
 4 Transketolase tkt 702 75,877 k00615 COG0021 Cytoplasmic Absence GO:0008152 GO:0003824 GO:0004802 GO:0016740 GO:0046872 G
 5 50S ribosomal protein L25 rplY 206 21,815 k02897. COG1825 Cytoplasmic Absence GO:0006412 GO:0003723 GO:0003735 GO:0008097 GO:0019843 GO:0005840 GO:0030529 J
 6 Glyceraldehyde 3-phosphate dehydrogenase BMOU_0196 351 37,881 Cytoplasmic Absence GO:0006006 GO:0055114 GO:0016491 GO:0016620 GO:0050661 GO:0051287
 7 Glycine-tRNA ligase glyQS 446 52,295 k01880 COG0423 Cytoplasmic Absence GO:0006412 GO:0006418 GO:0006426 GO:0000166 GO:0004812 GO:0004820 GO:0005524 GO:0016874 GO:0046983 GO:0005737 J
 8 60 kDa chaperonin groL 541 56,837 k04077 COG0459 Cytoplasmic Absence GO:0006457 GO:0042026 GO:0000166 GO:0005524 GO:0051082 GO:0005737 O
 9 Elongation factor Tu tuf 399 43,936 k02358. COG0050 Cytoplasmic Absence GO:0006412 GO:0006414 GO:0000166 GO:0003746 GO:0003924 GO:0005525 GO:0005622 GO:0005737 J
 10 Xylose isomerase xylA 449 50,765 k01805 COG2115 Cytoplasmic Absence GO:0005975 GO:0006098 GO:0042732 GO:0000287 GO:0009045 GO:0016853 GO:0046872 GO:0005737 G
 11 ABC transporter substrate-binding protein BBPC_1795 430 47,488 K10117 COG1653 Cytoplasmic Absence GO:0006810 GO:0005215 G
 12 Elongation factor Ts tsf 283 29,835 k02357 COG0264 Cytoplasmic Absence GO:0006412 GO:0006414 GO:0003746 GO:0005622 GO:0005737 J
 13 Transaldolase tal 367 39,871 k00616 COG0176 Cytoplasmic Absence GO:0005975 GO:0006098 GO:0003824 GO:0004801 GO:0016740 GO:0005737 G
 14 ABC transporter substrate-binding protein BBPC_1231 550 59,251 K15580 COG4166 Cytoplasmic Absence GO:0055085 GO:0043190 E
Proteins specific for patients’ intestinal microbiota compared with the normal
 1 Ketol-acid reductoisomerase ilvC 350 38,768 Cytoplasmic Absence GO:0008652 GO:0009082 GO:0009097 GO:0009099 GO:0055114 GO:0004455 GO:0016491 GO:0016853
 2 Phosphoglycerate kinase pgp 401 41,995 k00927 COG0126 Cytoplasmic Absence GO:0006096 GO:0016310 GO:0000166 GO:0004618 GO:0005524 GO:0016301 GO:0016740 GO:0005737 G
 3 50S ribosomal protein L4 rplD 221 23,761 K02926 COG0088 Unknown Absence GO:0006412 GO:0003723 GO:0003735 GO:0019843 GO:0005840 GO:0030529 J
 4 Ribose-phosphate pyrophosphokinase prs 337 36,843 K00948 COG0462 Cytoplasmic Absence GO:0006015 GO:0009165 GO:0016310 GO:0000166 GO:0000287 GO:0004749 GO:0005524 GO:0016301 GO:0016740 GO:0046872 GO:0005737 F E
 5 Probable thiol peroxidase tpx 171 18,391 K11065 COG2077 Periplasmic Absence GO:0005623 GO:0045454 GO:0055114 GO:0098869 GO:0004601 GO:0008379 GO:0016209 GO:0016491 GO:0016684 GO:0005623 O
 6 30S ribosomal protein S4 rpsD 208 23,719 K02986 COG0522 Cytoplasmic Absence GO:0006412 GO:0003723 GO:0003735 GO:0019843 GO:0005622 GO:0005840 GO:0015935 GO:0030529 J
 7 50S ribosomal protein L3 rplC 213 22,687 K02906 COG0087 Cytoplasmic Absence GO:0006412 GO:0003723 GO:0003735 GO:0019843 GO:0005622 GO:0005840 GO:0030529 J
  1. aCategories were taken from the TIGR-CMR (www.tigr.org) and the abbreviation was used to mark the categories. J Translation, O Posttranslational modification, protein turnover, chaperones, G Carbohydrate transport and metabolism, E Amino acid transport and metabolism, F Nucleotide transport and metabolism; —: not in COGs