Table 3 Characteristics of proteins with enhanced expression level in the fecal microbiota from LC patients or specific for patients’ intestinal microbiota compared with the normal

 1

Chaperone protein DnaK

dnaK

620

66,266

k04043

COG0443

Cytoplasmic

Absence

GO:0006457 GO:0000166 GO:0005524 GO:0051082

O

 2

Glutamate dehydrogenase

proS

604

66,842

k01881

COG0442

Cytoplasmic

Absence

GO:0006520 GO:0055114 GO:0016491 GO:0016639

J

 3

Elongation factor G

fusA

709

78,383

k02355

COG0480

Cytoplasmic

Absence

GO:0006412 GO:0006414 GO:0000166 GO:0003746 GO:0003924 GO:0005525 GO:0005622 GO:0005737

J

 4

Transketolase

tkt

702

75,877

k00615

COG0021

Cytoplasmic

Absence

GO:0008152 GO:0003824 GO:0004802 GO:0016740 GO:0046872

G

 5

50S ribosomal protein L25

rplY

206

21,815

k02897.

COG1825

Cytoplasmic

Absence

GO:0006412 GO:0003723 GO:0003735 GO:0008097 GO:0019843 GO:0005840 GO:0030529

J

 6

Glyceraldehyde 3-phosphate dehydrogenase

BMOU_0196

351

37,881

—

—

Cytoplasmic

Absence

GO:0006006 GO:0055114 GO:0016491 GO:0016620 GO:0050661 GO:0051287

—

 7

Glycine-tRNA ligase

glyQS

446

52,295

k01880

COG0423

Cytoplasmic

Absence

GO:0006412 GO:0006418 GO:0006426 GO:0000166 GO:0004812 GO:0004820 GO:0005524 GO:0016874 GO:0046983 GO:0005737

J

 8

60 kDa chaperonin

groL

541

56,837

k04077

COG0459

Cytoplasmic

Absence

GO:0006457 GO:0042026 GO:0000166 GO:0005524 GO:0051082 GO:0005737

O

 9

Elongation factor Tu

tuf

399

43,936

k02358.

COG0050

Cytoplasmic

Absence

GO:0006412 GO:0006414 GO:0000166 GO:0003746 GO:0003924 GO:0005525 GO:0005622 GO:0005737

J

 10

Xylose isomerase

xylA

449

50,765

k01805

COG2115

Cytoplasmic

Absence

GO:0005975 GO:0006098 GO:0042732 GO:0000287 GO:0009045 GO:0016853 GO:0046872 GO:0005737

G

 11

ABC transporter substrate-binding protein

BBPC_1795

430

47,488

K10117

COG1653

Cytoplasmic

Absence

GO:0006810 GO:0005215

G

 12

Elongation factor Ts

tsf

283

29,835

k02357

COG0264

Cytoplasmic

Absence

GO:0006412 GO:0006414 GO:0003746 GO:0005622 GO:0005737

J

 13

Transaldolase

tal

367

39,871

k00616

COG0176

Cytoplasmic

Absence

GO:0005975 GO:0006098 GO:0003824 GO:0004801 GO:0016740 GO:0005737

G

 14

ABC transporter substrate-binding protein

BBPC_1231

550

59,251

K15580

COG4166

Cytoplasmic

Absence

GO:0055085 GO:0043190

E

 1

Ketol-acid reductoisomerase

ilvC

350

38,768

—

—

Cytoplasmic

Absence

GO:0008652 GO:0009082 GO:0009097 GO:0009099 GO:0055114 GO:0004455 GO:0016491 GO:0016853

—

 2

Phosphoglycerate kinase

pgp

401

41,995

k00927

COG0126

Cytoplasmic

Absence

GO:0006096 GO:0016310 GO:0000166 GO:0004618 GO:0005524 GO:0016301 GO:0016740 GO:0005737

G

 3

50S ribosomal protein L4

rplD

221

23,761

K02926

COG0088

Unknown

Absence

GO:0006412 GO:0003723 GO:0003735 GO:0019843 GO:0005840 GO:0030529

J

 4

Ribose-phosphate pyrophosphokinase

prs

337

36,843

K00948

COG0462

Cytoplasmic

Absence

GO:0006015 GO:0009165 GO:0016310 GO:0000166 GO:0000287 GO:0004749 GO:0005524 GO:0016301 GO:0016740 GO:0046872 GO:0005737

F E

 5

Probable thiol peroxidase

tpx

171

18,391

K11065

COG2077

Periplasmic

Absence

GO:0005623 GO:0045454 GO:0055114 GO:0098869 GO:0004601 GO:0008379 GO:0016209 GO:0016491 GO:0016684 GO:0005623

O

 6

30S ribosomal protein S4

rpsD

208

23,719

K02986

COG0522

Cytoplasmic

Absence

GO:0006412 GO:0003723 GO:0003735 GO:0019843 GO:0005622 GO:0005840 GO:0015935 GO:0030529

J

 7

50S ribosomal protein L3

rplC

213

22,687

K02906

COG0087

Cytoplasmic

Absence

GO:0006412 GO:0003723 GO:0003735 GO:0019843 GO:0005622 GO:0005840 GO:0030529

J