Table 2 Univariate and multivariate analysis of determinants of altered transaminases
a) Univariate analysis | ||||
Variables | No liver dysfunction (n = 348) | Liver dysfunction (n = 58) | OR | P value |
Age, years (Mean ± SD) | 44.6 ± 15.1 | 46.6 ± 12.1 | -- | 0.333 |
Age at diagnosis, years (Mean ± SD) | 35.5 ± 14.0 | 36.8 ± 13.7 | -- | 0.481 |
Sex, male (n; %) | 206 (59.2 %) | 35 (60.3) | 0.953 | 0.869 |
Crohn’s vs ulcerative colitis (ratio) | 0.775 | 1.43 | 0.588 | 0.063 |
Previous surgery (n; %) | 42 (12.1) | 16 (27.6) | 2.776 | 0.002 |
Use of 5-ASA (n; %) | 177 (50.9) | 17 (29.3) | 0.401 | 0.003 |
Use of thiopurines (n; %) | 130 (37.3) | 31 (53.4) | 1.908 | 0.024 |
Use of steroids (n; %) | 42 (12.1) | 18 (31.0) | 3.279 | <0.001 |
Use of anti-TNF agents (n; %) | 7 (2.0) | 2 (3.4) | 1.74 | 0.497 |
HBsAg positivity (n; %) | 17 (4.9) | 6 (10.3) | 2.24 | 0.104 |
HBV and thiopurines (n; %) | 10 (3) | 3 (5.2) | 1.833 | 0.369 |
HBV and steroids (n; %) | 3 (0.6) | 3 (1.7) | 3.035 | 0.368 |
HBV and anti-TNF agents (n; %) | 1 (0.3) | 1 (1.7) | 6.088 | 0.204 |
b) Multivariate analysis | ||||
OR (95 % CI) | P value | |||
Crohn’s vs ulcerative colitis | 0.834 (0.467–1.858) | 0.589 | ||
Previous Surgery | 2.330 (1.107–4.906) | 0.026 | ||
5-ASA | 0.428 (0.197–1.163) | 0.058 | ||
Steroids | 2.524 (1.394–6.450) | 0.010 | ||
Thiopurines | 0.698 (0.307–1.695) | 0.411 | ||