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Table 3 Associations of pancreatic cancer with polymorphisms in genes involved in folate metabolism by smoking and drinking status

From: Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects

  Case patients (n = 360) Control subjects (n = 400) Multivariable-adjusted OR 95 % CI Casepatients (n = 360) Control subjects (n = 400) Multivariable-adjusted OR 95 % CI P for interaction
MTHFR_C677T rs1801133 Never smokers    Ever smokers    
CC 48 63 1.00   79 61 1.00   
CT 61 89 0.83 0.49-1.40 100 105 0.80 0.51-1.26  
TT 36 50 0.91 0.50-1.66 36 32 1.02 0.55-1.87 0.94
MTHFR_A1298C rs1801131
AA 95 143 1.00   145 142 1.00   
AC 45 53 1.39 0.84-2.29 62 49 1.24 0.78-1.96  
CC 5 6 1.71 0.49-6.00 8 7 1.12 0.38-3.28 0.83
MTRR_A66G rs1801394
AA 61 101 1.00   106 105 1.00   
AG 69 82 1.37 0.86-2.18 88 76 1.16 0.75-1.79  
GG 15 19 1.21 0.56-2.62 21 17 1.09 0.52-2.26 0.46
MTR_A2756G rs1805087
AA 98 127 1.00   126 114 1.00   
AG 41 69 0.73 0.44-1.19 76 73 1.08 0.70-1.66  
GG 6 6 1.61 0.48-5.40 13 11 1.35 0.56-3.24 0.93
MTHFR_C677T rs1801133 Never drinkers    Ever drinkers    
CC 47 54 1.00   80 70 1.00   
CT 58 66 1.05 0.60-1.82 103 128 0.74 0.48-1.16  
TT 29 27 1.33 0.67-2.64 43 55 0.81 0.47-1.40 0.41
MTHFR_A1298C rs1801131
AA 88 101 1.00   152 184 1.00   
AC 39 40 1.16 0.67-2.01 68 62 1.40 0.90-2.16  
CC 7 6 1.43 0.44-4.61 6 7 1.06 0.32-3.55 0.78
MTRR_A66G rs1801394
AA 58 67 1.00   109 139 1.00   
AG 56 66 1.03 0.61-1.73 101 92 1.45 0.96-2.19  
GG 20 14 1.61 0.73-3.56 16 22 0.78 0.37-1.65 0.15
MTR_A2756G rs1805087
AA 87 86 1.00   137 155 1.00   
AG 43 57 0.78 0.47-1.32 74 85 0.98 0.64-1.50  
GG 4 4 1.49 0.35-6.38 15 13 1.59 0.69-3.65 0.57
  1. OR was adjusted for age, sex, BMI and history of diabetes