| Case patients (n = 360) | Control subjects (n = 400) | Multivariable-adjusted OR | 95 % CI | Casepatients (n = 360) | Control subjects (n = 400) | Multivariable-adjusted OR | 95 % CI | P for interaction |
---|---|---|---|---|---|---|---|---|---|
MTHFR_C677T rs1801133 | Never smokers | Â | Â | Ever smokers | Â | Â | Â | ||
CC | 48 | 63 | 1.00 | Â | 79 | 61 | 1.00 | Â | Â |
CT | 61 | 89 | 0.83 | 0.49-1.40 | 100 | 105 | 0.80 | 0.51-1.26 | Â |
TT | 36 | 50 | 0.91 | 0.50-1.66 | 36 | 32 | 1.02 | 0.55-1.87 | 0.94 |
MTHFR_A1298C rs1801131 | |||||||||
AA | 95 | 143 | 1.00 | Â | 145 | 142 | 1.00 | Â | Â |
AC | 45 | 53 | 1.39 | 0.84-2.29 | 62 | 49 | 1.24 | 0.78-1.96 | Â |
CC | 5 | 6 | 1.71 | 0.49-6.00 | 8 | 7 | 1.12 | 0.38-3.28 | 0.83 |
MTRR_A66G rs1801394 | |||||||||
AA | 61 | 101 | 1.00 | Â | 106 | 105 | 1.00 | Â | Â |
AG | 69 | 82 | 1.37 | 0.86-2.18 | 88 | 76 | 1.16 | 0.75-1.79 | Â |
GG | 15 | 19 | 1.21 | 0.56-2.62 | 21 | 17 | 1.09 | 0.52-2.26 | 0.46 |
MTR_A2756G rs1805087 | |||||||||
AA | 98 | 127 | 1.00 | Â | 126 | 114 | 1.00 | Â | Â |
AG | 41 | 69 | 0.73 | 0.44-1.19 | 76 | 73 | 1.08 | 0.70-1.66 | Â |
GG | 6 | 6 | 1.61 | 0.48-5.40 | 13 | 11 | 1.35 | 0.56-3.24 | 0.93 |
MTHFR_C677T rs1801133 | Never drinkers | Â | Â | Ever drinkers | Â | Â | Â | ||
CC | 47 | 54 | 1.00 | Â | 80 | 70 | 1.00 | Â | Â |
CT | 58 | 66 | 1.05 | 0.60-1.82 | 103 | 128 | 0.74 | 0.48-1.16 | Â |
TT | 29 | 27 | 1.33 | 0.67-2.64 | 43 | 55 | 0.81 | 0.47-1.40 | 0.41 |
MTHFR_A1298C rs1801131 | |||||||||
AA | 88 | 101 | 1.00 | Â | 152 | 184 | 1.00 | Â | Â |
AC | 39 | 40 | 1.16 | 0.67-2.01 | 68 | 62 | 1.40 | 0.90-2.16 | Â |
CC | 7 | 6 | 1.43 | 0.44-4.61 | 6 | 7 | 1.06 | 0.32-3.55 | 0.78 |
MTRR_A66G rs1801394 | |||||||||
AA | 58 | 67 | 1.00 | Â | 109 | 139 | 1.00 | Â | Â |
AG | 56 | 66 | 1.03 | 0.61-1.73 | 101 | 92 | 1.45 | 0.96-2.19 | Â |
GG | 20 | 14 | 1.61 | 0.73-3.56 | 16 | 22 | 0.78 | 0.37-1.65 | 0.15 |
MTR_A2756G rs1805087 | |||||||||
AA | 87 | 86 | 1.00 | Â | 137 | 155 | 1.00 | Â | Â |
AG | 43 | 57 | 0.78 | 0.47-1.32 | 74 | 85 | 0.98 | 0.64-1.50 | Â |
GG | 4 | 4 | 1.49 | 0.35-6.38 | 15 | 13 | 1.59 | 0.69-3.65 | 0.57 |