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Table 3 Associations of pancreatic cancer with polymorphisms in genes involved in folate metabolism by smoking and drinking status

From: Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects

 

Case patients (n = 360)

Control subjects (n = 400)

Multivariable-adjusted OR

95 % CI

Casepatients (n = 360)

Control subjects (n = 400)

Multivariable-adjusted OR

95 % CI

P for interaction

MTHFR_C677T rs1801133

Never smokers

  

Ever smokers

   

CC

48

63

1.00

 

79

61

1.00

  

CT

61

89

0.83

0.49-1.40

100

105

0.80

0.51-1.26

 

TT

36

50

0.91

0.50-1.66

36

32

1.02

0.55-1.87

0.94

MTHFR_A1298C rs1801131

AA

95

143

1.00

 

145

142

1.00

  

AC

45

53

1.39

0.84-2.29

62

49

1.24

0.78-1.96

 

CC

5

6

1.71

0.49-6.00

8

7

1.12

0.38-3.28

0.83

MTRR_A66G rs1801394

AA

61

101

1.00

 

106

105

1.00

  

AG

69

82

1.37

0.86-2.18

88

76

1.16

0.75-1.79

 

GG

15

19

1.21

0.56-2.62

21

17

1.09

0.52-2.26

0.46

MTR_A2756G rs1805087

AA

98

127

1.00

 

126

114

1.00

  

AG

41

69

0.73

0.44-1.19

76

73

1.08

0.70-1.66

 

GG

6

6

1.61

0.48-5.40

13

11

1.35

0.56-3.24

0.93

MTHFR_C677T rs1801133

Never drinkers

  

Ever drinkers

   

CC

47

54

1.00

 

80

70

1.00

  

CT

58

66

1.05

0.60-1.82

103

128

0.74

0.48-1.16

 

TT

29

27

1.33

0.67-2.64

43

55

0.81

0.47-1.40

0.41

MTHFR_A1298C rs1801131

AA

88

101

1.00

 

152

184

1.00

  

AC

39

40

1.16

0.67-2.01

68

62

1.40

0.90-2.16

 

CC

7

6

1.43

0.44-4.61

6

7

1.06

0.32-3.55

0.78

MTRR_A66G rs1801394

AA

58

67

1.00

 

109

139

1.00

  

AG

56

66

1.03

0.61-1.73

101

92

1.45

0.96-2.19

 

GG

20

14

1.61

0.73-3.56

16

22

0.78

0.37-1.65

0.15

MTR_A2756G rs1805087

AA

87

86

1.00

 

137

155

1.00

  

AG

43

57

0.78

0.47-1.32

74

85

0.98

0.64-1.50

 

GG

4

4

1.49

0.35-6.38

15

13

1.59

0.69-3.65

0.57

  1. OR was adjusted for age, sex, BMI and history of diabetes