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Table 2 Associations of pancreatic cancer with folate metabolizing gene polymorphisms

From: Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects

  Case patients (n = 360) Control subjects (n = 400) Crude OR 95 % CI Multivariable-adjusted OR* 95 % CI P for trend**
MTHFR_C677T rs1801133
CC 127 124 1.00   1.00   
CT 161 194 0.81 0.59-1.12 0.87 0.62-1.22  
TT 72 82 0.86 0.57-1.28 0.99 0.65-1.51 0.86
MTHFR_A1298C rs1801131
AA 240 285 1.00   1.00   
AC 107 102 1.25 0.90-1.72 1.28 0.91-1.80  
CC 13 13 1.19 0.54-2.61 1.22 0.53-2.80 0.17
MTRR_A66G rs1801394
AA 167 206 1.00   1.00   
AG 157 158 1.23 0.91-1.66 1.29 0.94-1.77  
GG 36 36 1.23 0.74-2.04 1.12 0.66-1.91 0.27
MTR_A2756G rs1805087
AA 224 241 1.00   1.00   
AG 117 142 0.89 0.65-1.20 0.87 0.63-1.21  
GG 19 17 1.20 0.61-2.37 1.53 0.75-3.12 0.89
  1. OR odds ratio, CI confidence interval
  2. *OR was adjusted for age, sex, cigarette smoking, BMI, and history of diabetes
  3. **P for trend is shown for multivariable-adjusted OR