Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects

BMC Gastroenterology

Table 2 Associations of pancreatic cancer with folate metabolizing gene polymorphisms

	Case patients (n = 360)	Control subjects (n = 400)	Crude OR	95 % CI	Multivariable-adjusted OR*	95 % CI	P for trend**
MTHFR_C677T rs1801133
CC	127	124	1.00		1.00
CT	161	194	0.81	0.59-1.12	0.87	0.62-1.22
TT	72	82	0.86	0.57-1.28	0.99	0.65-1.51	0.86
MTHFR_A1298C rs1801131
AA	240	285	1.00		1.00
AC	107	102	1.25	0.90-1.72	1.28	0.91-1.80
CC	13	13	1.19	0.54-2.61	1.22	0.53-2.80	0.17
MTRR_A66G rs1801394
AA	167	206	1.00		1.00
AG	157	158	1.23	0.91-1.66	1.29	0.94-1.77
GG	36	36	1.23	0.74-2.04	1.12	0.66-1.91	0.27
MTR_A2756G rs1805087
AA	224	241	1.00		1.00
AG	117	142	0.89	0.65-1.20	0.87	0.63-1.21
GG	19	17	1.20	0.61-2.37	1.53	0.75-3.12	0.89

ISSN: 1471-230X